UNLABELLED Drugs that inhibit the sodium-glucose co-transporter-2 (SGLT2) are an exciting novel, insulin-independent treatment for diabetes that block glucose reabsorption from the proximal tubules of the kidney, leading to increased glucose excretion and lower blood glucose levels. Inhibition of SGLT2 activity also reduces sodium reabsorption, which together with glycosuria produces a mild diu...

In order to investigate the syndrome of postobstructive diuresis, clearance and micropuncture studies were carried out in rats after relief of 24 hr of bilateral (BUL) or unilateral (UUL) ureteral ligation. In rats with BUL, a striking diuresis and natriuresis occurred when the obstruction to one kidney (the experimental kidney) was relieved. The results were not influenced by administration of...

The effect of acute extracellular volume expansion with saline on the intrarenal distribution of glomerular filtrate, was studied in dogs utilizing micropuncture techniques in which samples were obtained by both recollection and from new tubules. Recollection was examined in seven dogs during continuous hydropenia and in five dogs during continuous saline diuresis. Recollection was associated w...

INTRODUCTION In-hospital hypernatremia is associated with increased mortality rates. We want to elucidate the impact of in-hospital acquired hypernatremia in mortality of Toxic Epidermal Necrolysis (TEN). PURPOSE Is there an association between hypernatremia and mortality in patients with TEN? METHOD Retrospective study of 25 patients with TEN. Laboratory electrolyte results, diuresis and s...

MALVIN, RICHARD L. AND WALTER S. WILDE. Washout of renal countercurrent Na gradient by osmotic diuresis. Am. J. Physiol. 197(I): 177-180. I g5g.-The antidiuretic hormone regulates the ability of the kidney to concentrate urine. There are two theories as to the nature of the renal concentrating mechanism: I) the existence of an active water pump in a distal area which removes free water from the...

Chronic cold exposure causes hypertension and diuresis. The aim of this study was to determine whether vasopressin (AVP) plays a role in cold-induced hypertension and diuresis. Two groups of Long-Evans (LE) and two groups of homozygous AVP-deficient Brattleboro (VD) rats were used. Blood pressure (BP) was not different among the four groups during a 2-wk control period at room temperature (25 d...

Background. In adult female mosquitoes, the renal (Malpighian) tubules play an important role in the post-prandial diuresis, which removes excess ions and water from the hemolymph of mosquitoes following a blood meal. After the post-prandial diuresis, the roles that Malpighian tubules play in the processing of blood meals are not well described. Methods. We used a combination of next-generation...

Rhodnius prolixus , a major vector of Chagas disease, may be considered the model upon which foundations insect physiology and biochemistry were built. It is an obligate blood feeder in meal triggers growth, development reproduction. The also post-prandial diuresis to maintain osmotic homeostasis. In R. as with other insects, Malpighian tubules play critical role this diuresis, much has been le...