Pretargeting techniques have shown promise for enhancement of the therapeutic index of radioimmunotherapy for cancer. However, methods to vary and compare antibody configurations and select optimal combinations have proved rather formidable. New options for the construction of pretargeting molecules are provided by sophisticated use of the diversity and malleability of antibody genes. Diverse a...

We present the characterization of additional properties of the night-sky at the Calar Alto observatory, following the study started in Sánchez et al. (2007), hereafter Paper I. We focus here on the night sky-brightness at the near-infrared, the telescope seeing, and the fraction of useful time at the observatory. For this study we have collected a large dataset comprising 7311 near-infrared im...

In 1924, Los Angeles was the largest city in the West, the largest in land area and the fifth largest city in the United States. Tourism, a land boom, emerging industries, and a new harbor had made Los Angeles prosper. There were one million residents in Los Angeles and, whether native born or migrants seeking a fortune or retirement haven, all enjoyed and extolled Los Angeles' one unchanging a...

In the 18th – early 19th century, in architecture of Europe, fashion for Orientalism began to appear, but this process started gain real strength second half 19th century during spread so-called neo-styles. The certain creative tribute enthusiasm oriental motives was given by most famous Kharkiv architect – academician O. M. Beketov. 1895–1910 he designed and built...

Background: Different strategies are being explored to maximise the effect of COVID-19 vaccination in Europe. We studied impact different population prioritisation and dose intervals on infections, hospitalisations, mortality, public health restrictions. Method: An agent-based model was built quantify over 6 months. Input parameters were derived from recent phase 3 trials official European f...

Objective: This work proposes a model of formation brand extension loyalty heritage parent based on the attitude towards parent, taking into account mediating effect image and moderating effects fit between as well involvement product category. Methodology: An experimental study has been carried out with 328 tourists visiting destination manipulating two levels adjustment. A moderate mediation ...

Background: The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is of particular concern for people with rheumatoid arthritis (RA), concerns that these may be at higher risk and have poorer outcomes. However, present implications RA remain poorly understood. Objectives: To investigate associations between diagnosis, hospitalisation COVID-19-rel...

The subject of rhythmic canons has been revivified by new concepts, coming from the field of music composition. The present article is a survey of the mathematical knowledge in this field, from the 1950’s to state of the art results. 1 What is this all about ? Paving the way 1.1 Rhythmic canons and tiling I was introduced to the fascinating subject of rhythmic canons by people working at the Ir...