No: 687 Health and Hygiene 329 EVALUATION OF THE IMPACT OF TABLET SPLITTING ON THE ACCURACY OF DRUG DOSING H.S. Sellahewa and H.M.D.R. Herath* Department of Pharmacy, Faculty of Allied Health Sciences, University of Peradeniya, Sri Lanka *[email protected] Tablet splitting is commonly used in pharmacy practice. There are many reasons to split tablets such as to get the prescribed dose, to ad...

the present investigation was designed to formulate a natural tablet for the treatment of vaginal candidiasis in order to eliminate side effects that are caused by existing antifungal drugs. curcumin has promising antifungal activity in comparison with the existing azole antifungal drugs. bioadhesive curcumin vaginal tablets were prepared by direct compression with different ratios of biadhesiv...

In this study 50 samples of ecstasy tablets seized in Iran during the period of 2007 through 2008 were examined and their physical characteristics (appearance, marking, scored/not scored, color, weight, diameter, thickness) were determined. In order to determine the chemical characteristics of these tablets, color tests (Marquis test, Simon’s test, Chen’s test and Gallic acid test), Thin Layer ...

Inoperable c- kit negative gastrointestinal stromal tumor (GIST) is commonly considered to be highly resistant to systemic therapy. We present a case of a woman with an abdominal sarcomalike tumor diagnosed at the age of 26. The patient underwent several surgical procedures and courses of cytostatic therapy without any substantial effect. Later, the tumor was reclassified as c- kit negative GIS...

Imatinib mesylate was approved for the treatment of chronic myelogenous leukemia more than 5 years ago. This drug enabled us to put a very high percentage of patients into hematologic, cytogenetic, and molecular remission. Some patients were resistant to Imatinib from the onset of the treatment whereas others became resistant after showing an initial response to Imatinib mesylate. Various strat...

Chronic myeloid leukaemia (CML) is a form of leukaemia derived from the myeloid cell lineage. Imatinib mesylate, the breakpoint cluster region-abelson murine leukeamia kinase inhibitor, is a specific reagent used in the clinical treatment of CML. The DNA topoisomerase II inhibitor, etoposide, is also employed as a therapeutic, though it is used to a lesser extent. The present study aims to eval...

This study investigates the impact of relative air humidity and temperature on the stability of imidapril hydrochloride (IMD) tablets. For this purpose the forced degradation test was used and the following environmental conditions were employed: RH = 76.4% and the temperature range of 313 - 333 K. For the determination of IMD content in the analyzed samples a reversed-phase high performance li...

Many antiepileptic drugs (AEDs) are extended-release (ER) tablets, such that an entire day’s dose is taken only once or twice daily. A patient taking four levetiracetam ER 500 mg tablets twice daily was alarmed when, after switching from a generic manufactured by Sun to a generic manufactured by Lupin, ER tablet remnants appeared as intact tablets in his stool, suggesting no drug was absorbed. ...

in this study, attempts were made to evaluate the effect of various acrylic acid based carbopols on the release profile of a beta-adrenoreceptor blocking drug, propranolol hcl, from matrix-type tablets invitro. for this purpose, tablets containing 160 mg of propranolol hcl along with various amounts of carbopols 934 (c934), 971 (c971), 974 (c974) and pemulen (pem) were prepared using the wet gr...