Sensory processing disorder, characterized by over- or under-responsivity to non-noxious environmental stimuli, is a common but poorly understood disorder. We examined the role of prenatal alcohol exposure, serotonin transporter gene polymorphic region variation (rh5-HTTLPR), and striatal dopamine (DA) function on behavioral measures of sensory responsivity to repeated non-noxious sensory stimu...

Alcohol use disorder is a leading cause of preventable death with serious consequences in many domains. There is an increasing need to fine tune detection and diagnostic methods to enable health care workers prevent, diagnose and manage this disorder. The diagnosis of an alcohol problem could be quite a challenge as the disorder can present as other psychiatric syndromes. The diagnostic armamen...

Among a nationally representative sample of adults with an alcohol use disorder, the authors tested whether perceived stigmatization of alcoholism was associated with a lower likelihood of receiving alcohol-related services. Data were drawn from a face-to-face epidemiologic survey of 34,653 adults interviewed in 2004-2005 who were aged 20 years or older and residing in households and group quar...

BACKGROUND Alcohol dependence is a complex psychological disorder whose phenomenology changes as the disorder progresses. Neuroscience has provided a variety of theories and evidence for the development, maintenance, and severity of addiction; however, clinically, it has been difficult to evaluate alcohol use disorder (AUD) severity. OBJECTIVE This study seeks to evaluate and validate a data-...

Abstract In this paper, I examine Reinforcement Learning (RL) modelling practice in psychiatry, the context of alcohol use disorders. argue that epistemic roles RL currently plays development psychiatric classification and search for explanations clinically relevant phenomena are best appreciated terms Chang’s (2004) account iteration, by distinguishing mechanistic aetiological modes computatio...

OBJECTIVE The purpose of this study was to examine the relationship between alcohol exposure in pregnancy and offspring conduct disorder symptoms in adolescence and to examine how much this increasingly known association may be mediated by maternal and paternal externalizing diagnoses, including lifetime maternal and paternal alcohol and drug abuse/dependence diagnoses as well as antisocial dis...

Fetal alcohol spectrum disorder (FASD) is a leading cause of neurodevelopmental disability. Individuals with FASD may exhibit a characteristic facial appearance that has diagnostic utility. The mechanism by which alcohol disrupts craniofacial development is incompletely understood, as are the genetic factors that can modify individual alcohol vulnerability. Using an established avian model, we ...