نتایج جستجو برای: airway reactivity

تعداد نتایج: 138470  

Journal: :Hypertension 2011
Mehmood Butt Omer A Khair Girish Dwivedi Alena Shantsila Eduard Shantsila Gregory Y H Lip

Obstructive sleep apnea is associated with increased cardiovascular morbidity and mortality. We investigated myocardial perfusion using real-time quantitative myocardial contrast echocardiography with concurrent assessment of macrovascular and microvascular endothelial dysfunction in normotensive subjects with moderate-to-severe obstructive sleep apnea, who were compared with hypertensive and h...

Journal: :Canadian journal of anaesthesia = Journal canadien d'anesthesie 2000
P Matthey P Wang B A Finegan M Donnelly

PURPOSE To report a case of anaphylaxis to rocuronium and the sensitivities to multiple neuromuscular blocking drugs in a patient with no previous exposure to this group of drugs. We describe the current recommendations for both intraoperative and postoperative testing of these patients. CLINICAL FEATURES A 36-yr-old man was admitted for repair of a ruptured Achilles tendon. Following inducti...

Journal: :The European respiratory journal 1992
J P Finnerty A Harvey S T Holgate

It has been proposed that exercise provokes bronchoconstriction in asthma by inducing mast cell degranulation, and that this occurs secondary to the hyperpnoea of exercise causing hypertonicity of the airway lining fluid. We investigated the contribution of the mast cell products, histamine and prostaglandins, to the bronchoconstriction induced by isocapnic hyperventilation (ISH) using single d...

Journal: :Paediatric respiratory reviews 2004
Donald Payne Andrew Bush

Most children with asthma can be treated successfully with low-to-moderate doses of inhaled corticosteroid and long-acting beta-2 agonist. Those that fail to respond are a heterogeneous group. We propose that the nature and type of any steroid-resistant inflammation, the extent of any persistent airflow limitation and the extent of bronchial hyper-reactivity should be determined separately to a...

Journal: :Clinical science 2013
Simon G Royce Amelia Sedjahtera Chrishan S Samuel Mimi L K Tang

Although CSs (corticosteroids) demonstrate potent effects in the control of airway inflammation in asthma, many patients continue to experience symptoms and AHR (airway hyper-responsiveness) despite optimal treatment with these agents, probably due to progressive airway remodelling. Identifying novel therapies that can target airway remodelling and/or airway reactivity may improve symptom contr...

Journal: :Journal of applied physiology 2003
Angelo Corsico Manlio Milanese Simonetta Baraldo Gian Luca Casoni Alberto Papi Anna Maria Riccio Isa Cerveri Marina Saetta Vito Brusasco

This study investigated the relationships between pathological changes in small airways (<6 mm perimeter) and lung function in 22 nonasthmatic subjects (20 smokers) undergoing lung resection for peripheral lesions. Preoperative pulmonary function tests revealed airway obstruction [ratio of forced expiratory volume in 1 s to forced vital capacity (FEV1/FVC) < 70%] in 12 subjects and normal lung ...

Journal: :The Journal of pharmacology and experimental therapeutics 2005
Peter J Oldenburg S Jamal Mustafa

In allergen-induced asthma, activation of lung mast cells leads to bronchial constriction, increased mucus secretion, and an increase in the localization of inflammatory cells to the airways. The purpose of this study was to explore the role of mast cells in adenosine-mediated airway reactivity and inflammation using the mast cell degranulating agent, compound 48/80 (C48/80). Mice were sensitiz...

Journal: :Journal of applied physiology 2001
T J Wetter C M St Croix D F Pegelow D A Sonetti J A Dempsey

Seventeen fit women ran to exhaustion (14 +/- 4 min) at a constant speed and grade, reaching 95 +/- 3% of maximal O(2) consumption. Pre- and postexercise lung function, including airway resistance [total respiratory resistance (Rrs)] across a range of oscillation frequencies, was measured, and, on a separate day, airway reactivity was assessed via methacholine challenge. Arterial O(2) saturatio...

2012
Eun-Jung Kim Sang-Wook Shin Tae-Kyun Kim Ji-Uk Yoon Gyeong-Jo Byeon Hye-Jin Kim

BACKGROUND Desflurane has the most rapid onset and offset of action among the volatile anesthetic agents used for general anesthesia, but it can cause airway reactivity, tachycardia, and hypertension during induction, especially in pediatric patients. This study was designed to determine a median effective effect-site concentration (EC(50)) of remifentanil to prevent the cardiovascular changes ...

Journal: :The Journal of pharmacology and experimental therapeutics 2007
Hiroaki Kume Naoya Takeda Tetsuya Oguma Satoru Ito Masashi Kondo Yasushi Ito Kaoru Shimokata

In the present study, we investigated whether extracellular sphingosine 1-phosphate (S1P) is involved in airway hyper-reactivity in bronchial asthma. The effects of S1P on the response to methacholine was examined in the fura-2-loaded strips of guinea pig tracheal smooth muscle using simultaneous recording of the isometric tension and the ratio of fluorescence intensities at 340 and 380 nm (F(3...

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