Increased cap-dependent mRNA translation rates are frequently observed in human cancers. Mechanistically, many human tumors often overexpress the cap binding protein eukaryotic translation initiation factor 4E (eIF4E), leading to enhanced translation of numerous tumor-promoting genes. In this issue of the JCI, Graff and colleagues describe potent antitumor effects using second-generation antise...

NeuroBridges grew from the friendship between Ahmed El Hady, an Egyptian neuroscientist at Princeton University, and his Israeli colleague Yonatan Loewenstein of the Edmond & Lily Safra Center for Brain Sciences (ELSC) at the Hebrew University of Jerusalem. After they met in Germany, Loewenstein invited El Hady to an ELSC retreat in Ein Gedi, an oasis near the Dead Sea in Israel. During a hike,...

ANXIETY AND ANGER ARE RIFE AMONG THE BIOMEDICAL RESEARCH COMMUNITY OVER THE dwindling fortunes of the National Institutes of Health (NIH). The anxiety is justified: Success rates for grant applications have fallen, on average, from over 30% in 2003 to under 20% (and to even less at some Institutes), and the Bush administration’s budget projections imply further declines. But the anger is anothe...