the anti-apoptotic gene bcl-2 is located in mitochondria, but it is uncertain whether its expression affects hepatocyte survival in ischemia/reperfusion (i/r) injury. this experiment was designed to evaluate the role of folic acid in expression of bcl-2 in i/r in rat liver. eighteen wister rats were divided into sham-operated controlgroup (c) (n=6), i/r group (n=6), folic acid treated group whi...

background: the interaction between follicular cells and oocyte leads to a change in gene expression involved in oocyte maturation processes. objective: the purpose of this study was to quantify the expression of more common genes involved in follicular growth and oocyte developmental competence. materials and methods: in this experimental study, the expression of genes was evaluated with qrt-p...

background currently, there are evidences for the existence of diverse strains of helicobacter pylori with different levels of virulence. in other way, the most important reason of therapeutic failure is resistance to the antibiotics. objectives the aim of this study was to evaluate the relationship between h. pylori drug resistance and the presence of caga gene. patients and methods gastric bi...

background: pro-inflammatory and anti-inflammatory cytokines and polymorphisms of their genes have been described to be involved in the pathogenesis of recurrent miscarriage (rm). objective: to investigate the association between rm and five polymorphisms of cytokine genes, interleukin 10 (il-10), (-592 a/c, -819 c/t, -1082 a/g), il-6 (-174 c/g) and il-17 (-197 g/a) in iranian women. method: po...

background: in this study, we evaluated the incidence of apoptosis at the ultrastructural levels and expression of some apoptosis-related genes in vitrified human ovarian tissue just after warming. methods: human ovarian tissue biopsies from 23 women after caesarean section were transported to the laboratory within 2 hours, and then they were cut into small pieces. some pieces were vitrified an...

channel activities, particularly those of calcium channels, have vital roles in the process of sperm maturation, motility and sperm-egg interaction. a group of the recently discovered ion channels associated with these processes is four novel channel-like proteins known as catsper (cation channel sperm) gene family. catsper1 and catsper2 show sperm specific expression patterns. however, neither...

tuberculosis is one of the most common infectious diseases in the world. in recent years, genetically approach has been developed. one of the interesting gene for investigator is ifn-γr1. in this study we determind susceptibility to tuberculosis with polymorphism of ifn-γr1 gene. fifthly patients with smear positive tuberculosis have been chosen randomly. they were matched with 54 healthy contr...

to determine the association between polymorphism of ugt1a1 gene and idiopathic hyperbilirubinemia in iranian neonates. fifty neonates with idiopathic hyperbilirubinemia and serum total bilirubin (stb) more that 15mg/dl and 50 neonates with idiopathic hyperbilirubinemia and serum total bilirubin (stb) less than 15mg/dl enrolled in this study. thymine-adenine (ta)  repeats in the promoter region...

background: salmonella enterica serovar typhi (s. typhi) the cause of the acute febrile disease typhoid fever is the major public health problem in developing countries. asymptomatic carriers are the main sources of typhoid. the aim of this study was to investigate methods for isolation and identification of s. typhi in asymptomatic carriers. materials and methods: two hundred stool samples wer...

introduction: gestational diabetes mellitus (gdm) is defined as abnormal glucose tolerance that is first identified or diagnosedduring pregnancy.deiodinase d2 is essential for the local production of t3 through deiodination of triiodothyroxine (t4). several polymorphisms in d2 have been described. the single-nucleotide polymorphism (snp) in d2 thr92ala is associated with decreased enzyme activi...