aggregation operators (aos) have been studied by many schol- ars. as many aos are proposed, there is still lacking approach to classify the categories of ao, and to select the appropriate ao within the ao candidates. in this research, each ao can be regarded as a cognitive style or individual dierence. a cognitive style and aggregation operator (csao) model is pro- posed to analyze the mapping ...

This paper presents a mathematical model for evaluating the impact of information aggregation on the performance of PNNIdriven ATM networks. The routing aggregation scheme, required for optimizing PNNI-driven networks, but not specified by the standards, affects both performances (e.g. call blocking rate and route length) and scalability (e.g. routing table size and routing decision complexity)...

Background & Aims: Alzheimer's disease is a neurodegenerative disorder characterized by the abnormal aggregation of amyloid-β plaques in the brain. Although several studies have been done for finding effective medicines in the treatment of this disease, a drug that inhibits amyloid β aggregation and ameliorates the disorder has not been approved so far. One important therapeutic approach is use...

Let F be a set of M classification procedures with values in [−1, 1]. Given a loss function, we want to construct a procedure which mimics at the best possible rate the best procedure in F . This fastest rate is called optimal rate of aggregation. Considering a continuous scale of loss functions with various types of convexity, we prove that optimal rates of aggregation can be either ((logM)/n)...

Mitochondrial heat-shock protein 70 (mtHsp70) and its partner proteins drive protein import into the matrix. Tim15/Zim17/Hep1 is a mtHsp70 partner protein on the matrix side of the inner mitochondrial membrane. We determined the nuclear magnetic resonance (NMR) structure of the core domain of Tim15. On the basis of the NMR structure, we created Tim15 mutants and tested their ability to compleme...

It is known in thin-film deposition that the density of nucleated clusters N varies with the deposition rate F as a power law, N ∼ Fα. The exponent α is a function of the critical nucleus size i in a way that changes with the aggregation limiting process. We extend here the derivation of the analytical capture-zone distribution function Pβ(s) = aß ·sβ ·exp(-bβs2) of Pimpinelli and Einstein to g...

Background: Coagulation activity of platelets plays an important role in thrombosis formation, Atherosclerotic plaque establishment and cardiovascular disorders. ASA are using as an anti platelet activity drug for patients with Coronary Artery Disease (CAD). Using of plant extraction as a complementary medicine for these patients (CAD) is mostly recommended by traditional medicine specialist. ...

Background: DAB389IL-2 is considered a fusion immunotoxin and it is used for the CTCL therapy. DAB389IL-2 includes of two distinct portions; the catalytic domain of diphtheria toxin and IL-2. DAB389IL-2 duo to the presence of a free cysteine residue (Cys 513 in IL-2 part) is prone to unwanted intramolecular and intermolecular disulfide bonds formation and aggregation problems. Aggregation is co...

Lysine acetylation is becoming increasingly recognized as a general biological principle in cellular homeostasis, and is subject to abnormal control in different human pathologies. Here, we describe a global effect on amyloid-like protein aggregation in human cells that results from aberrant lysine acetylation. Bromodomain reader proteins are involved in the aggregation process and, using chemi...