Bone cancer pain is the most severe among cancer pain and is often resistant to current analgesics. Thus, the development of novel analgesics effective at treating bone cancer pain are desired. Platelet-activating factor (PAF) receptor antagonists were recently demonstrated to have effective pain relieving effects on neuropathic pain in several animal models. The present study examined the pain...

INTRODUCTION Nine cases of visceral leishmaniasis occurred recently in Barra Mansa, State of Rio de Janeiro, with a high mortality rate. METHODS We reviewed the medical records of the patients. RESULTS Eight were male; 7 were adults. Patients who died progressed to death quickly and presented with aggravating factors: systemic steroid therapy before diagnosis, bleeding, severe liver involve...

The glucose paradox of cerebral ischemia (namely, the aggravation of delayed ischemic neuronal damage by preischemic hyperglycemia) has been promoted as proof that lactic acidosis is a detrimental factor in this brain disorder. Recent studies, both in vitro and in vivo, have demonstrated lactate as an excellent aerobic energy substrate in the brain, and possibly a crucial one immediately postis...

OBJECTIVE To describe the use of symptom-relieving drugs (antimuscarinic drugs or duloxetine) before and after surgery for urinary incontinence (UI); and for those with use of antimuscarinic drugs or duloxetine before surgery, to estimate the risk of being a postoperative user, relative to those without use before surgery. DESIGN A historical population-based cohort study. SETTING Denmark. ...

Acetaminophen, also known as APAP or paracetamol, is one of the most widely used analgesics (pain reliever) and antipyretics (fever reducer). According to the U.S. Food and Drug Administration, currently there are 235 approved prescription and over-the-counter drug products containing acetaminophen as an active ingredient. When used as directed, acetaminophen is very safe and effective; however...

parents who have a baby with infantile colic experienced a different thought and emotions such as hopelessness, fatigue and impasses. in this study, our living experience as a professional nursing parents' are represented with new relieving modality for infantile colic. herein, we report a new relieving dietary protocol for a colicky infant with non- immunoglobulin e – mediated protein ind...

background: factor v g1691a (fv leiden), fii ga20210, and methylenetetrahydrofolate reductase (mthfr) c677t mutations are the most common genetic risk factors for thromboembolism in the western countries. however, there is rare data in iran about cerebral venous and sinus thrombosis (cvst) patients. the aim of this study was to evaluate the frequency of common genetic thrombophilic factors in c...