introduction: this study carried out to investigate the causes and motivations of older people residing in nursing home. methods: a qualitative description study was designed by choosing a sample of the elderly residing in a nursing home in tabriz, iran. based on purposive sampling, fifteen residents in the age range of 65-85 participated in the study. data was collected through unstructured in...

background: ethical issues are essential components in any piece of research. in fact, they ought to be considered during designing, planning and conducting each research study particularly among the vulnerable. the aim of this paper is to describe and explain some of the ethical issues and challenges faced by a researcher who carried out a research in three malaysian residential homes. materia...

conclusions high quality research is needed to establish the true portray for the prevalence and severity of vasomotor and sexual symptoms associated with distress in iranian women. context the aim of this study was to systematically review published articles reporting on the prevalence of vasomotor and sexual symptoms in iranian women. evidence acquisition five databases including medline, psy...

Age-related hearing loss (presbycusis) is a common human disorder, affecting one in three Americans aged 60 and over. Previous studies have shown that presbyacusis is associated with a loss of non-sensory cells in the cochlear lateral wall. Sox10 is a transcription factor crucial to the development and maintenance of neural crest-derived cells including some non-sensory cell types in the cochle...

the transcriptional factor oct4 regulates pluripotency of stem cells and has an important role during oocyte growth. whereas, its role has remained ambiguous in ovarian tissue during reproductive cycle. therefore, this study was aimed to investigate the expression patterns of oct4 in mouse ovaries during the normal estrous cycle. adult national medical research institute mice were classified as...

background: nicotine exposure causes impaired fertility and ovarian dysfunction. the aim of this study was to investigate the possible protective role of melatonin, which is known as an antioxidant agent on altered ovarian functions upon nicotine exposure. methods: a total of 32 female adult nmri mice were divided randomly into four groups (n=8). the control group received vehicle, while group ...

nicotine is one the chemical substance with high level of toxically. it crosses the placenta and accumulates in the developing organs of fetus. our previous investigations indicated that collagen type iv plays a key role in basement membrane of various embryonic organs. in this study we evaluated the effect of maternal nicotine exposure pre and postnatal period on collagen iv expression during ...

protein tyrosine phosphatases (ptpases) regulate the tyrosine phosphorylation of target proteins in volved in several biological activities including cell proliferation and transformation. protein tyrosine phosphatase e (ptpe) contains duplicated ptpase-like domains and a short extracellular region. us ing the fluorescence in situ hybridization method, the gene encoding ptpe (locus symbol ptpre...

Caffeine, as an oocyte aging inhibitor, was used in many different species to control or delay oocyte aging. However, the safety of caffeine and developmental competence of aged oocytes inhibited by caffeine has not been studied systematically. So we detected the spindle morphology, distribution of cortical granules, zona pellucida hardening and pronucleus formation to assess oocyte quality of ...