The organization of energy metabolism was assessed in erythrocytes of the sea raven {Hemitripterus americanus). Cell suspensions displayed a potential for aerobic glycolysis, shown by the presence of the glycolytic enzymes phosphofructokinase, aldolase and pyruvate kinase and the mitochondrial markers citrate synthase and malate dehydrogenase. Rates of oxygen uptake {MQ^} and glucose uptake Mg\...

Mitomycin C (MC) is a naturally occurring anticancer agent which has been shownto be more cytotoxicto hypoxictumor cells than to their aerobic counterparts. The mechanism of action of this agent is thought to involvebiologicalreductiveactivation,to a speciesthat alkylutes DNA. A comparisonof the cytotoxicityof MC to EMT6 tumor cells with that of the structural analogues porfiromycin(PM), .•V-...

The present paper has examined the degrading ability of phenol-oxidizing bacterium, Ralstonia eutropha, for biological removal of methylene blue (MB) from aqueous solutions under aerobic conditions. Results show that MB has been extensively eliminated as a co-metabolism in the presence of supplementary carbon (glucose) and nitrogen (yeast extract and peptone) sources and the experimental observ...

Lactate accumulation in tumors has been associated with metastases and poor overall survival in cancer patients. Lactate promotes angiogenesis and metastasis, providing rationale for understanding how it is processed by cells. The concentration of lactate in tumors is a balance between the amount produced, amount carried away by vasculature and if/how it is catabolized by aerobic tumor or strom...

Tamoxifen resistance is often observed in the majority of estrogen receptor-positive breast cancers and it remains as a serious clinical problem in breast cancer management. Increased aerobic glycolysis has been proposed as one of the mechanisms for acquired resistance to chemotherapeutic agents in breast cancer cells such as adriamycin. Herein, we report that the glycolysis rates in LCC2 and L...

Mitomycin C (MC) is a naturally occurring anticancer agent which has been shown to be more cytotoxic to hypoxic tumor cells than to their aerobic counterparts. The mechanism of action of this agent is thought to involve biological reductive activation, to a species that alkylates DNA. A comparison of the cytotoxicity of MC to EMT6 tumor cells with that of the structural analogues porfiromycin (...

Title: DNA SEQUENCE VARIATION IN THE PROMOTER REGION OF THE VEGF GENE: IMPACTS ON VEGF GENE EXPRESSION AND MAXIMAL OXYGEN CONSUMPTION Steven John Prior, Ph.D., 2005 Directed By: Assistant Professor Stephen M. Roth, Department of Kinesiology Maximal oxygen consumption (Vo2max) is inversely associated with cardiovascular and all-cause mortality and is responsive to aerobic exercise training. A po...

BACKGROUND Human BarH-like homeobox 2 (Barx2), a homeodomain factor of the Bar family, plays a critical role in cell adhesion and cytoskeleton remodeling, and has been reported in an increasing array of tumor types except non-small cell lung carcinoma (NSCLC). The purpose of the current study was to characterize the expression of Barx2 and assess the clinical significance of Barx2 in NSCLC. M...

OBJECTIVES To determine the effects of aerobic and power exercise training on haemostatic factors after coronary artery surgery and to compare the effect of the two exercise programmes. DESIGN A prospective randomised controlled study of six months aerobic and power exercise training in men after coronary artery surgery. SETTING Exercise rehabilitation classes in a teaching hospital in Glas...

there are confirmed beneficiary effects of exercise on atherosclerotic inflammation of ischemia-associated heart diseases. the purpose of this study was to evaluate the effect of aerobic exercise on t-regulatory cell markers of il-35 as well as foxp3 and t-helper2 marker of il-33 in patients with ischemic heart disease (ihd). this research was performed on 44 asymptomatic male patients with isc...