BACKGROUND Numerous reporting biases have been known to affect spontaneous reporting databases. The Weber effect, which constitutes a peak in adverse event (AE) reporting of a drug at the end of second year after regulatory approval followed by a continuous decline thereafter, has been considered an important bias for a long time. The existence of this bias in AE reporting of oncology drugs rem...

In order to investigate detailed features of the space-time distributions of microfractures generated during rock fracture experiments, we have developed a high-speed, multi-channel acoustic emission (AE) waveform measurement system. This system consists of 32 channels of transient-memory controlled by a microcomputer. The transient-memory has a 16 MB RAM buffer in each channel, which enables u...

BACKGROUND Pulmonary artery (PA) balloon angioplasty and/or stenting (PA rehabilitation) is one of the most common procedures performed in the cardiac catheterization laboratory, but comprehensive and consistently reported data on procedure-related adverse events (AE) are scarce. METHODS AND RESULTS Data were prospectively collected using a multicenter registry (Congenital Cardiac Catheteriza...

Recently, research has progressively highlighted on clues from conventional use of herbal medicines to introduce new anticancer drugs. Aloe-emodin (AE) is a herbal drug with promising anticancer activity. Nevertheless, its clinical utility is handicapped by its low solubility. For the first time, this study aims to the fabrication of surface-functionalized polyethylene glycol liquid crystalline...

The paper deals with the review of acoustic emission technique in biomedical field. The review is done with the aim to provide an overview of the use of AE technique in biomedical field, mainly concentrated on the AE behavior of bone under different loading conditions, its dependence on strain rate, in osteoporosis, monitoring the fracture healing process of bone. The overall conclusion from th...

Acute exacerbation (AE) of idiopathic pulmonary fibrosis (IPF) results in poor survival. The objective of the present study was to elucidate the impact of asymmetrical ground-glass opacity (GGO) and/or consolidation on outcomes in patients with AE-IPF. The cases of 59 consecutive patients with AE-IPF were retrospectively reviewed. High-resolution computed tomography (HRCT) at diagnosis of an AE...

Background and objectives: Dracocephalum kotschyi is a plant which belongs to the Lamiaceae family and exists mostly in south-west Asian countries, including Iran. This plant is used as antispasmodic, analgesic and anti-inflammatory to treat rheumatoid diseases. Methods: In order to investigate the impact of the harvesting time changes on the quantity and quality of mono- and sesquiter...

It has been reported that the aqueous extract of pomegranate (AE-PG) has polyphenols with estrogenic-like activities. The present work determines if AE-PG alone or in combination with the selective serotonin reuptake inhibitor, citalopram, has antidepressant-like effects. It was also analyzed the participation of estrogen receptors (ER). AE-PG (0.1, 1.0, 10, or 100 mg/kg) was evaluated in ovari...

  In this study we investigated the bronchodilatory and anticholinergic effects of the aqueous extract (AE), brewed extract (BE) and ethanol extract (EE) of Polygonum avicular in comparison with saline (S) on isolated tracheal chains of the guinea pig. Due to the probable confounding effect of ethanol in the EE, the effects of this extract were also compared with 96 % ethanol. None of the plant...

The aim of this study was to evaluate the effects of Aloe vera extract (AE) on the immunity responses and hematological parameters in rainbow trout (Oncorhynchus mykiss) fry to develop alternative drug to chemotherapeutics and antibiotics in aquaculture. 1200 rainbow trout (Oncorynchus mykiss) fry weighing 2±0.2 gram were randomly allocated into two treatment groups i...