background: vitamin d supplementation during pregnancy has been supposed to defend against adverse gestational outcomes. objective: this randomized clinical trial study was conducted to assess the effects of 50,000 iu of vitamin d every two weeks supplementation on the incidence of gestational diabetes (gdm), gestational hypertension, preeclampsia and preterm labor, vitamin d status at term and...

INTRODUCTION Intimate partner violence (IPV) is a public health problem that affects millions of women worldwide. The role of violence as an underlying factor in poor birth outcomes remains an area where strong evidence is lacking. The aim of this study was to determine the association between intimate partner violence (IPV) and preterm delivery (PTB) and low birth weight (LBW). MATERIALS AND...

Targeted therapies have drastically changed the management of metastatic melanoma and have shown encouraging results on tumour progression but are also known for their high rates of adverse reactions. In general, targeted therapies are contraindicated during pregnancy due to concerns about teratogenesis. For the BRAF V600 inhibitor vemurafenib, the available literature about the effects on huma...

BACKGROUND Recent studies suggest that periodontal disease, as a source of subclinical and persistent infection, may induce systemic inflammatory responses that increase the risk of adverse pregnancy outcomes. OBJECTIVES To examine the existing evidence on the relationship between periodontal disease and adverse pregnancy outcomes. SEARCH STRATEGY Published studies identified via searches o...

AIMS Data regarding pregnancy outcome in women with congenital heart disease (CHD) are limited. METHODS AND RESULTS In 1802 women with CHD, 1302 completed pregnancies were observed. Independent predictors of cardiac, obstetric, and neonatal complications were calculated using logistic regression. The most prevalent cardiac complications during pregnancy were arrhythmias (4.7%) and heart failu...

Background: The role of anticoagulant medications in preventing placental mediated pregnancy complications in patients with and without thrombophilia has not been investigated well. One underlying cause is associated with adverse effects of anticoagulants in pregnancy including teratogenicity, complexities in dosing and management of anticoagulants during pregnancy and labor. We aimed to assess...

The prevalence of pregnancy associated leukemia is approximately 1 case out of 10,000 pregnancies. This rare occurrence precludes the conducting of large, prospective studies to examine diagnostic, management and outcome issues. The treatment of a pregnant woman with leukemia may be associated with severe adverse fetal outcome including death and malformations, and therefore poses a difficult c...

Objective: one of the best tests for the assessment of a fetus is the biophysical profile test which has a significant effect on fetus health and the outcome of pregnancy. The present study was designed to determine the relationship between the full biophysical profile and the rapid biophysical profile tests in antepartum fetal surveillance. Patients and Methods: In this prospective study, Sin...

Background: Objectives of current study were to study the significance of Doppler in PIH using middle cerebral artery and umbilical artery blood flow and to analyze the role of Doppler in PIH in predicting perinatal outcome. Methods: Hundred cases of women with pregnancy induced hypertension between 28-40 weeks of gestation were studied for umbilical artery and middle cerebral artery Doppler wa...

BACKGROUND Q fever has become a major public health problem in The Netherlands. Infection with Coxiella burnetii (Q fever) during pregnancy has resulted in adverse pregnancy outcome in the majority of reported cases. Therefore, we aimed to quantify this risk by examining the earliest periods corresponding to the epidemic in The Netherlands. METHODS Serum samples that had been collected from t...