Chronic exposure to manganese (Mn) produces a spectrum of cognitive and behavioral deficits associated with a neurodegenerative disorder resembling Parkinson's disease. The effects of high-dose exposure to Mn in occupational cohorts and in adult rodent models of the disease are well described but much less is known about the behavioral and neurochemical effects of Mn in the developing brain. We...

Busulfan is known to cause several adverse effects including reproductive toxicity in humans. Garlic (Allium sativum), a widely distributed medicinal plant, is highly regarded for its medicinal activities including antioxidant property.This study was conducted to assess whether garlic extract could serve as protective agents against testicular toxicity during busulfan treatment in a mi...

Objective: Female metabolism is highly responding towards diet associated changes. Monosodium glutamate is a popular flavor enhancer, which is widely used to develop umami taste. Young female generation nowadays deals with more issues related to metabolism and fertility. Present study is an effort to monitor the effect of monosodium glutamate oral consumption on female mice health and obesity. ...

Objective: This study was undertaken to evaluate the effect of vestibular stimulation on motor coordination in Parkinson’s disease (PD) induced mice. Methods: 18 healthy adult male Swiss albino mice were used this study. Vestibule stimulated by caloric (CVS). Pesticide Rotenone induce (PD). Motor assessed fall-off time and activity score using rotarod actophotometer, respectively. Results: In t...

Due to the ozone layer depletion an increased global warming observed, which allows UVB radiation penetrate atmosphere and have deadly effects on people. It is thought that short- long-term are exposed daily has biological organisms humans. Concerning effect of radiations, we examine automatic mechanism by a specific amount induces oxidative stress hyperthyroidism. For these examinations 12 adu...

Selective Clara cell injury produced by many bioactivated lung toxicants is thought to result from high levels of activating enzymes found in differentiated Clara cells. A recent study found an elevated susceptibility to the Clara cell toxicant 4-ipomeanol in neonatal rabbits when Clara cell P450 activity is low. To determine whether differentiating Clara cells in another species (mouse) are mo...

Abstract Obesity is a major risk factor underlying the development of metabolic disease and growing public health concern globally. Strategies to promote skeletal muscle metabolism can be effective limit progression disease. Here, we demonstrate that levels Hippo pathway transcriptional co-activator YAP are decreased in biopsies from obese, insulin-resistant humans mice. Targeted disruption Yap...

The disruption of the nerve growth factor (NGF) gene in transgenic mice leads to a lethal phenotype (Crowley et al., 1994) and hinders the study of NGF functions in the adult. In this study the phenotypic knockout of NGF in adult mice was achieved by expressing transgenic anti-NGF antibodies, under the control of the human cytomegalovirus promoter. In adult mice, antibody levels are 2000-fold h...

OBJECTIVE Oximes are important materials in organic chemistry. Synparamethyl benzal- dehyde oxime (toloaldoxime) is structurally similar to other oximes, hence we have studied its effects on the neonatal and adult female Balb/c mice reproductive systems in order to provide a platform for future studies on the production of female contraceptive drugs. MATERIALS AND METHODS In experimental stud...