The present study was designed to examine the specificity of (3-adrenergic antagonists for al-, 192-adrenergic and 5HT1B-serotonergic receptors by the compe titive interaction with 1251-iodocyanopindolol (1251-ICYP) as a radioligand. The 81 -adrenoceptors were preferred by acebutolol, atenolol, betaxolol, practolol, and I-, dl and d-metoprolol, while butoxamine and ICI-118,551 preferred 82-adre...

Studies have found a link between chronic stress and anxiety disorders as well as major depressive disorder. This article reviews literature based on that keeping in view the physiology of stress and its consequences on psychological well-being of a person. If untreated, stress however downplayed at times, could be hazardous. INTRODUCTION The word stress implies an experience of negative emotio...

The objective of the current study was to develop a simple, precise and accurate isocratic reversed-phase highperformance liquid chromatography (RP-HPLC) method for the simultaneous estimation of salbutamol sulphate, theophylline and furosemide in synthetic mixture. Isocratic RP-HPLC separation was achieved on an Hibar 250 × 4.6 mm HPLC column Purosphens STAR RP-18, using a mobile phase of meth...

-Quantitative and qualitative changes in adrenoceptors under various conditions were studied by binding experiments. Chronic treatment with reserpine increased the level of a2-adrenoceptors in rat vas deferens and hypoxia increased the level of a1 -adrenoceptors in rat cardiomyocytes. Adenosine receptor agonists increased the affinity of the a2-adrenoceptor in rat vas deferens for the agonist w...

The effects of phenylephrine and methoxamine were studied on pacemaker activity in the sinoatrial node and on atrial and ventricular contractility in isolated, blood-perfused atrial and ventricular preparations of dogs. Each drug was administered directly into the cannulated sinus node artery of an isolated atrium or the anterior descending branch of the isolated left ventricle over a period of...

In rat hypothalamic slices, L-aromatic amino acid decarboxylase (AADC) was assayed, and the actions of L-DOPA on impulse (2 Hz)-evoked norepinephrine (NE) and dopamine (DA) release were studied under inhibition of AADC. Slices were incubated with L-DOPA, and DA and NE produced by conversion of the precursor were analyzed by high performance liquid chromatography with electro chemical detection ...

Gynec. Invest. 1974;5:7-64 Scientific Abstracts 1 Systemic and Pulmonary Hemodynamic Resposes to Neurotransmitters during Fetal Development B. Nuwayhid, C. Brinkman, III, J. Bevan, C. Su and N.S. Assali Department of Obstetrics-Gynecology and Pharmacology, University of California, Los Angeles, Calif., USA Development of vascular receptors in pulmonary and systemic circulations and their reacti...

Gynec. Invest. 1974;5:7-64 Scientific Abstracts 1 Systemic and Pulmonary Hemodynamic Resposes to Neurotransmitters during Fetal Development B. Nuwayhid, C. Brinkman, III, J. Bevan, C. Su and N.S. Assali Department of Obstetrics-Gynecology and Pharmacology, University of California, Los Angeles, Calif., USA Development of vascular receptors in pulmonary and systemic circulations and their reacti...