objective: in the present study, we examined the effects of memantine administration within the nucleus accumbens on the alterations in brain and adrenal volumes and weight ratios induced by stress from electric foot shock. methods: a group of mice received various doses of memantine (0.1, 0.5 and 1 mg/kg) prior to induction of stress. another group underwent intra-accumbal cannulation after an...

We assessed the usefulness and reliability of computed tomography (CT scan) in evaluating adrenal hyperplasia in 38 patients, including 14 with Cushing's disease, 17 with idiopathic hyperaldosteronism (IHA), and 7 with the adrenogenital syndrome (AGS). Eighty-two normal subjects were also examined. We analyzed the shape of the adrenal gland and quantitated its thickness, width and length. Visua...

It is well known that hippocampal LTP is modulated by corticosteroids released from the adrenal glands, and the activity of adrenal glands, in turn, is influenced by hippocampal activity through the Hypothalamic-Pituitary-Adrenocortical (HPA) axis. In the present research, we studied the relationship between hippocampal plasticity and the weight of adrenal glands, an indicator for the accumulat...

Adenomatoid tumors of adrenal gland are rare, asymptomatic neoplasias, with benign behavior, and usually are diagnosed incidentally. We report a case of a voluminous adenomatoid tumor of left adrenal gland in a 42-year old man who sought evaluation because of renal colic due to left nephrolithiasis. During the investigation, a tumor localized in left adrenal gland was identified by ultrasonogra...

Activins and inhibins are structurally related glycoprotein hormones modulating pituitary FSH secretion and gonadal steroidogenesis. Activins and inhibins are also produced in the adrenal cortex where their physiological role is poorly known. Hormonally active human adrenocortical tumors express and secrete inhibins, while in mice adrenal inhibins may function as tumor suppressors. To clarify t...

Putrescine is the major source of y-aminobutyric acid (GABA) in the rat adrenal gland. Diamine oxidase, and not monoamine oxidase, is essential for GABA formation from putrescine in the adrenal gland. Aminoguanidine, a diamine oxidase inhibitor, decreases the GABA concentration in the adrenal gland by more then 70 % after 4 h, and almost to zero in 24 h. Studies using [14C]putrescine confirm th...

Recent work by Woolley, Fekete, and Little (6, 8) has demonstrated that in certain inbred strains of mice striking changes in the adrenal cortex follow early castration. The female mice of the dilute brown (Dba) strain, castrated at birth, showed areas of nodular hyperplasia in the adrenal cortex, after one year involving and partly replacing all three zones of the cortex. These mice also showe...

The effects of chronic treatments with SRIH-14 and octreotide on pituitary corticotropes (ACTH cells) and on the adrenal cortex of male Wistar rats were examined. Adult males received two daily s.c. injections of 20 microg/100 g of body weight of either SRIH-14 or octreotide for 28 consecutive days. ACTH cells were studied using a peroxidase-antiperoxidase immunocytochemical procedure. Morpho-m...

BACKGROUND Memantine attenuates heart stress due cold stress, however, no study focused its effects on liver and adrenal gland. We evaluated its effects on lipid depletion in adrenal gland and glycogen depletion in liver of rats exposed to cold stress. METHODS Male rats divided into 4 groups: 1)Control (CON); 2)Memantine (MEM); 3)Induced cold stress (IH) and; 4)Induced cold stress memantine (...