Scott W. Powell, Robert A. Houze, Jr. , Anil Kumar, and Sally A. McFarlane Department of Atmospheric Sciences, University of Washington, Seattle, Washington Hydrological Science Branch, NASA Goddard Space Flight Center, Greenbelt, Maryland Earth System Science Interdisciplinary Center, University of Maryland, College Park, Maryland Climate Physics Group, Pacific Northwest National Laboratory, R...

Chronic migraine (CM) is a common and disabling disorder that remains underdiagnosed and poorly treated. Significant unmet therapeutic needs add to the burden of this disorder; even when CM is recognized, effective treatment options are limited and randomized controlled trials supporting the use of various preventive medications are sparse. In this review, we discuss the available options for C...

Pain presents in 80% of patients with advanced cancer, and 30% have periods of increased pain due to fluctuating intensity, known as breakthrough cancer pain (BTcP). BTcP is high-intensity, short-duration pain occurring in several episodes per day and is non-responsive to treatment. The clinical approach to BTcP is variable. A review of the literature was performed to provide clinicians and pra...

The US Food and Drug Administration (FDA) has recently issued draft guidance on how it intends to regulate laboratory-developed tests, including genetic tests. This article argues that genetic tests differ from traditional targets of FDA regulation in both product as well as industry landscape, and that the FDA's traditional tools are ill-suited for regulating this space. While existing regulat...

The discovery that oral administration of the oxazine dye, Nile blue A, to tumor-bearing mice resulted in diffuse staining of the tumor cells and significant retardation of their growth (1) led to the investigation of all available oxazine dyes. Further reports (2, 3) describe the action of a few of these dyes not only on transplanted sarcomata, but also on primary induced sarcomata and spon ta...