Adjuvant chemotherapy using TS-1 or capecitabine plus oxaliplatin improves survival outcomes after radical gastrectomy, with both regimens showing similar efficacies.A total of 494 patients with stage II‒III gastric cancer who underwent curative D2 gastrectomy and received adjuvant chemotherapy from April 2004 to June 2014 were included in this study. 219 patients received TS-1, and 275 receive...

AIM To evaluate the differences in treatment response and the impact on survival with both oral agents (UFT and Capecitabine) as neoadjuvant chemotherapy administered concomitantly with radiotherapy. BACKGROUND There are still no studies comparing the use of neoadjuvant oral chemotherapy either with UFT plus Folinic acid or Capecitabine concomitant with radiotherapy in locally advanced rectal...

Background: The impact of NACT on immediate breast reconstruction outcomes remains unclear. We assessed the effect neoadjuvant chemotherapy (NACT) post-operative complications and delay to adjuvant therapy among women undergoing reconstructions.

Non-small cell lung cancer (NSCLC) constitutes approximately 85% of all lung cancers, with patients having a poor prognosis. Approximately one third of NSCLC patients present with early-stage disease in which potentially curative resection and multi-modality therapy. Although adjuvant chemotherapy is the standard practice for patients with stages I-III breast and colorectal cancer, the therapeu...

PURPOSE The present study was undertaken to evaluate the effects of adjuvant anthracycline-based chemotherapy on thiobarbituric acid reactive substances (TBARS) and superoxide dismutase (SOD) levels in patients with breast cancer who had undergone surgery. METHODS Body mass index (BMI), serum lipids (total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides), serum TBARS and SOD v...

OBJECTIVE The aim of this retrospective study is to evaluate the efficacy of adjuvant chemotherapy following radical hysterectomy for intermediate risk stage IB cervical cancer. METHODS From January 1993 to December 2007, a total of 100 patients of stage IB were enrolled in this study who had at least two of the following three intermediate risk factors (deep stromal invasion, lymphovascular ...

CD133 and cancer-testis antigens (CTAs) may be potential predicted markers of adjuvant chemotherapy or immune therapy, and they may be the independent prognostic factor of NSCLC. Nowadays, there is still no predictive biomarker identified for the use of adjuvant chemotherapy in non-small cell lung cancer (NSCLC) patients. To clarify the role of CD133 and CTAs as a predictive marker for adjuvant...

Advances have been made in the adjuvant therapy of colorectal cancers. Fluorouracil-based chemotherapy has now been demonstrated to improve long-term disease-free survival rates in patients with resected stage III colon cancer. Combined radiation therapy plus fluorouracil-based chemotherapy has been shown to improve both local control and disease-free survival in patients with stage II and III ...

The prognosis of early-stage endometrial cancer is favorable, even when treated using surgery alone, whereas recurrent cases or advanced cases (stage III or IV) with progression beyond the uterus have a poor prognosis1), and therapy for such cancers is still in the exploratory stages. Stage I and II cases are sometimes treated with adjuvant therapy to prevent recurrence after surgical therapy; ...

PURPOSE To conduct an economic evaluation of the 70-gene signature used to guide adjuvant chemotherapy decision making both in patients with node-negative breast cancer (NNBC) and in the subgroup of estrogen receptor (ER) -positive patients. PATIENTS AND METHODS We used a mixed approach combining patient-level data from a multicenter validation study of the 70-gene signature (untreated patien...