A number of human diseases, such as arthritis and atherosclerosis, include characteristic pathology in specific anatomical locations. Here we show transcriptomic differences in synovial fibroblasts from different joint locations and that HOX gene signatures reflect the joint-specific origins of mouse and human synovial fibroblasts and synovial tissues. Alongside DNA methylation and histone modi...

Crack propagation along one of the interfaces between a thin ductile adhesive layer and the elastic substrates it joins is considered. The layer is taken as being elastic-plastic, and the fracture process of the interface is modeled by a traction-separation law, characterized by the peak separation stress 6 and the work of separation per unit area To. Crack growth resistance curves for mode I l...

Experimental studies of hafting adhesives and modifications to compound tool components can demonstrate the extent to which human ancestors understood and exploited material properties only formally defined by science within the last century. Discoveries of Stone Age hafting adhesives at archaeological sites in Europe, the Middle East, and Africa have spurred experiments that sought to replicat...

While the geometry of aerospace assemblies is carefully controlled, for many industrial applications such as marine structures bond line thickness can vary significantly. In this study epoxy adhesive joints of different thicknesses between aluminium substrates have been characterized using physicochemical analyses (differential scanning calorimetry, DSC; dynamic mechanical analysis, DMA; spectr...

The present work provides a simple and precise thermo-mechanical model for the prediction of stress distributions in adhesive joints. A displacement-based derivation is applied, using general sandwich-type overlap region. For layer linear displacement approach proposed, which captures variation shear stresses through-thickness direction. covers various joint configurations with linear-elastic m...