Evidence suggests that the neural cell adhesion molecule (NCAM) is an important molecular constituent of adaptive and maladaptive circuit (re-)organization in the central nervous system. Here, we further investigate its putative involvement in amygdala and hippocampus functions during context fear memory formation. Using laser capture microdissection and quantitative RT-PCR, we show high NCAM m...

Human immunodeficiency virus-1 (HIV-1) is primarily transmitted sexually. Dendritic cells (DCs) in the subepithelium transmit HIV-1 to T cells through the C-type lectin DC-specific intercellular adhesion molecule (ICAM)-3-grabbing nonintegrin (DC-SIGN). However, the epithelial Langerhans cells (LCs) are the first DC subset to encounter HIV-1. It has generally been assumed that LCs mediate the t...

Fasciclin II (Fas II, the Drosophila homolog of the verteHoward Hughes Medical Institute brate immunoglobulin-related cell adhesion molecule, Center for Neurobiology and Behavior NCAM) is present on both the preand postsynaptic College of Physicians and Surgeons elements of the synapse, it is not required for initial, Columbia University activity-independent synapse formation. However, Fas New ...

Adhesion molecules are integral membrane proteins that have cytoplasmic, transmembrane and extracellular domains. Dozens of different adhesion molecules have been identified, but, adhesion molecules are conventionally divided into four main groups, each of which has a different function:

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Fragments of intercellular adhesion molecule 1 (ICAM- 1) containing only the two most N terminal of its five immunoglobulin SF domains bind to rhinovirus 3 with the same affinity and kinetics as a fragment with the entire extracellular domain. The fully active two-domain fragments contain 5 or 14 more residues than a previously described fragment that is only partially active. Comparison of X-r...

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