The synthesis and characterization of four compounds [M(η5-C5Me5)(N^N)Cl]PF6 [N^N=4,7-dichloro-1,10-phenanthroline with M=Rh, 1, M=Ir, 2, N^N=4'-(4-chlorophenyl)-2,2':6',2''-terpyridine in the κ2N,N'-coordination mode 3, 4] are described. All were characterized by spectroscopic means their molecular structures crystal confirmed single-crystal X-ray diffraction studies. cytotoxicity all was eval...

Cancer cells with immunogenic properties having altered protein glycosylation, modified blood group substances have been widely studied. Due to the genetic instability occurring during carcinogenesis glycosyltransferases may suffer from posttranslation sequence modification. The author describes 2 autopsy cases, where in background of unusual metastatic tumor presentation, incompatible antigeni...

Since malignant cells often have a high demand for iron, we hypothesize that breast cancer cells may alter the expression of iron transporter genes including iron importers [transferrin receptor (TFRC) and solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (SLC11A2)] and the iron exporter SLC40A1 (ferroportin), and additionally that the growth of breast cancer c...

Breast cancer is the most common primary source of orbital metastasis. Metastasis occurs through hematogenous spread and predominantly involves the choroid. We present a case of a metastatic subconjunctival mass associated with primary breast cancer. To our knowledge, this is the first reported case of its kind. A 41-year-old woman presented with complaints of conjunctival injection and a forei...

The Mucin 1 (MUC1) oncoprotein is aberrantly overexpressed in diverse human malignancies including breast and lung cancer. Although MUC1 modulates the activity of several transcription factors, there is no information regarding the effects of MUC1 on global gene expression patterns and the potential role of MUC1-induced genes in predicting outcome for cancer patients. We have developed an exper...

The median time of brain metastasis from the diagnosis of breast cancer is approximately 3 years. In this case report, a 69-year-old woman demonstrated cerebellar ataxia. Brain magnetic resonance imaging revealed enhanced lesions in bilateral cerebellar hemispheres. She had undergone surgery, radiation, and chemotherapy for uterine and breast cancer 24 years prior and 16 years prior, respective...

Background. Ovarian cancer is a very important pathology of the female reproductive system and tends to increase in incidence mortality rates around world. Despite fact that ovarian prevalence lower than breast cervical cancer, its rate three times higher. Aim. To analyze population Ukraine Sumy region 2014–2018. Methods. Data from National Cancer Register were used for this work. A statistical...

Obesity is an epidemic in the US and an established risk factor for breast cancer incidence and morbidity. In obese patients breast cancer is commonly more aggressive and associated with poor prognosis. The goal of our research is to develop safe and efficient novel therapies to treat aggressive breast tumors, like those in obese patients. To enhance drug uptake we intend to develop electro-end...

Activating KRAS mutations in lung adenocarcinoma are characterized with treatment resistance and poor prognosis. As a small molecule inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) tyrosine kinase, apatinib has been proven successful in advanced gastric cancer and breast cancer. In this study, we show the result of apatinib as salvage treatment in lung adenocarcinoma patien...

OBJECTIVE Forkhead box (FOX) proteins are important regulators of the epithelial-to-mesenchymal transition (EMT), which is the main mechanism of cancer metastasis. Different studies have shown their potential involvement in progression of cancer in different tissues such as breast, ovary and colorectum. In this study, we aimed to analyze the expression of genes encoding two FOX proteins in gast...