The diverse applicability of diazo compounds as versatile reagents has enlarged the chemical toolbox in organic synthesis. Over past few decades, transition metal-catalyzed compound activation ignited classical synthetic methodology via utilizing highly reactive metal carbenoid species. Many reviews have also appeared literature which discloses advantage and disadvantages compound. Recently, tr...

Sir, At the turn of the nineteenth century, Ehrlich focused on the selective staining of malaria-infected cells over noninfected cells, with methylene blue and acridine orange. On reviewing this information, two simple questions arose: why do these compounds selectively target parasite infected cells and can this information be used against the parasite? We propose the following: methylene blue...

Two biomarkers of exposure to cigarette smoke, 4-aminobiphenyl-hemoglobin (Hb) adducts and aromatic DNA adducts in lymphocytes, were determined from a population of 55 smokers and 4 nonsmokers. The levels of these adducts were related to daily cigarette consumption and also to (calculated) tar and nicotine intake. The Hb adduct levels seemed to correspond best to the number of cigarettes (cig) ...

Monoand poly-nuclear metal carbonyls, and substituted analogues, have been analysed in the presence of N3 − ions by negative-ion electrospray mass spectrometry. Most complexes yield the appropriate isocyanate-containing anions by conversion of a CO ligand to an NCO one with elimination of N2. In some cases [M+N3] − ions are observed; for species such as H2Os3(CO)10 or Ru5C(CO)15 these arise fro...

1. The characteristics of benzofuroxan (benzofurazan 1-oxide, benzo-2-oxa-1,3-diazole N-oxide) that relate to its application as a reactivity probe for the study of environments of thiol groups are discussed. 2. To establish a kinetic and mechanistic basis for its use as a probe, a kinetic study of its reaction with 2-mercaptoethanol was carried out. 3. This reaction appears to proceed by a rat...

A novel electron deficient 4,6-bis(trifluoromethyl)-1,3-phenylene diphosphinite ligand 4 was developed and synthesized. Reaction of Ir precursors with ligand 4 gave chloro(hydride) pincer complex 5, which demonstrated a higher TON in alkane dehydrogenation reactions compared to similar phosphinite based pre-catalysts. The formation of cyclooctene (COE) and tert-butylethylene adducts of the 14e ...

A series of [3]ferrocenophanes with functional P-E-P motifs (E = group 14 fragments) is reported. Out of these, the silicon compounds with the general formula Fe(C5H4PtBu)2SiXY (XY = Cl2, Br2, I2, H2, HCl) have been characterized by spectroscopic means and the bonding situation was analyzed using X-ray crystallography and quantum chemical calculations. Despite the two stereogenic phosphanyl cen...

The antioxidant activity of naturally occurring stilbene compounds piceatannol (PIC) and isorhapontigenin (ISO) scavenging two free radicals (NO and NO2) were studied using density functional theory (DFT) method. Four reaction mechanisms have been considered: hydrogen atom transfer (HAT), radical adduct formation (RAF), single electron transfer (SET), and sequential proton loss electron transfe...

Abnormal N-heterocyclic carbene (aNHC) adducts of zinc(II) (1) and aluminum(III) (2) were synthesized. The compounds were characterized by NMR spectroscopy and elemental analysis. The solid state structures of these complexes (1 and 2) were determined by single crystal X-ray study. Furthermore, these organozinc and organoaluminum adducts (1 and 2) were tested for the ring opening polymerization...

Twelve chiral and achiral self-assembling dendrons have been grafted onto a [60]fullerene hexa-adduct core by copper-catalyzed alkyne azide "click" cycloaddition. The structure adopted by these compounds was determined by the self-assembling peripheral dendrons. These twelve dendrons mediate the self-organisation of the dendronized [60]fullerene into a disc-shaped structure containing the [60]f...