The autonomic nervous system (ANS) conveys neuronal input from the brain to the stomach. We investigated mechanisms through which urocortin 1 (UCN1) injected intracerebroventricularly (ICV, 300 pmol/rat) inhibits circulating ghrelin in rats. This was achieved by assessing (1) the induction of c-fos gene expression as a marker of neuronal activation in specific hypothalamic and caudal brainstem ...

Näsman, J. 2001. Alpha-2 Adrenergic Receptors and Signal Transduction. Effector Output in Relation to G-Protein Coupling and Signalling Cross-Talk. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1105. 64 pp. Uppsala. ISBN 91-554-5195-0. The alpha-2 adrenergic receptor (α2-AR) subfamily includes three different subtypes, α2A-, α2Band...

In this paper we consider the issue of source clock frequency recovery in packet networks and propose a new adaptive clock method based on the Kalman filter (KF) with low-pass prefiltering—KALP (Kalman filter-based Adaptive clock method with Low-pass Prefiltering) in short. Noting that because of the difficulty in modeling as well as the nonwhite Gaussian nature of the packet jitter most existi...

Background—Recent studies of b-adrenergic receptor (b-AR) subtype signaling in in vitro preparations have raised doubts as to whether the cAMP/protein kinase A (PKA) signaling is activated in the same manner in response to b2-AR versus b1-AR stimulation. Methods and Results—The present study compared, in the intact dog, the magnitude and characteristics of chronotropic, inotropic, and lusitropi...

BACKGROUND Recent studies of beta-adrenergic receptor (beta-AR) subtype signaling in in vitro preparations have raised doubts as to whether the cAMP/protein kinase A (PKA) signaling is activated in the same manner in response to beta2-AR versus beta1-AR stimulation. METHODS AND RESULTS The present study compared, in the intact dog, the magnitude and characteristics of chronotropic, inotropic,...

Androgen receptor (AR) splice variants lacking the ligand binding domain (ARVs), originally isolated from prostate cancer cell lines derived from a single patient, are detected in normal and malignant human prostate tissue, with the highest levels observed in late stage, castration-resistant prostate cancer. The most studied variant (called AR-V7 or AR3) activates AR reporter genes in the absen...

The DNA-binding domains (DBDs) of class I steroid receptors-androgen, glucocorticoid, progesterone and mineralocorticoid receptors-recognize a similar cis-element, an inverted repeat of 5'-AGAACA-3' with a 3-nt spacer. However, these receptors regulate transcription programs that are largely receptor-specific. To address the role of the DBD in and of itself in ensuring specificity of androgen r...