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UNLABELLED The serotonergic system may play an important role in the pathophysiology of major depressive disorder (MDD). Few imaging studies have examined serotonin transporter (SERT) binding in patients with MDD. We hypothesized that SERT binding activity may be altered in patients with MDD. This study compared SERT binding in patients with MDD with that in healthy controls. METHODS We studi...
Received 1/9/2002; revised 2/27/2002; accepted 3/6/2002. For correspondence or reprints contact: Wen-Sheng Huang, M.D., Department of Nuclear Medicine, Tri-Service General Hospital, 325 Section 2, Cheng-Kung Road, Taipei 114, Taiwan, R.O.C. Tel: (886)2-87927374, Fax: (886)2-87927217, E-mail: [email protected] Background: Serotonin transporter (SERT) plays a major role in modulating seroto...
W hen ion concentrations differ on either side of a membrane, this produces a difference in electrical potential, or voltage, across the membrane. Neurons utilize this voltage to transmit information in the form of electrical signals. But might cell voltage also affect processes such as embryonic development or the behavior of yeast and other microbes? These questions cannot be answered using t...
Male hypogonadism, or testosterone deficiency syndrome (TDS), results from a failure of the testes to produce adequate androgen. Patients have low circulating testosterone in combination with clinical symptoms such as fatigue, erectile dysfunction, and body composition changes. The cause may be primary (genetic anomaly, Klinefelter's syndrome) or secondary (defect in hypothalamus or pituitary),...
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