We describe our experience with a juvenile patient who had refractory intestinal Behcet's disease that responded to adalimumab, a fully humanized antibody against soluble TNF-α and its receptor. The patient, a 13-year-old girl, presented with oral aphthous ulcers, vulvar pain, and rashes on the lower extremities. She gradually developed a low-grade fever, abdominal pain, diarrhea, and hematoche...

OBJECTIVE To evaluate the quality of life and economic impact of switching therapy from infliximab to adalimumab in patients with rheumatoid arthritis (RA). METHODS In this open-label study, patients demonstrating a clinical response to infliximab were switched to treatment with adalimumab and followed for 16 weeks. Both generic (Health Assessment Questionnaire and Short Form 36 Physical Comp...

We evaluated the efficacy, pharmacokinetics, and safety of adalimumab in Japanese patients with active ankylosing spondylitis (AS) who had an inadequate response to, or who were intolerant of, treatment with ≥1 nonsteroidal anti-inflammatory drugs (NSAIDs). This phase 3, multicenter, open-label trial assessed the percentage of patients with a 20% response in the Assessment of SpondyloArthritis ...

INTRODUCTION Adalimumab is a recombinant fully-human monoclonal immunoglobulin (IgG1) antibody utilized in the treatment of Crohn's disease. Unfortunately no clinical or genetic markers exist to predict response to anti-tumor necrosis factor-alpha (TNF) therapy. The aim of this study was to evaluate the association between selected genes involved in cytokine regulation and response to adalimuma...

Since the discovery of the role of tumor necrosis factor in the physiopathological process of rheumatoid arthritis, five drugs that block this cytokine have been used as therapeutic options. To evaluate the efficacy and safety of adalimumab in the treatment of rheumatoid arthritis we performed a systematic review and meta-analysis of randomized controlled trials. A search of relevant studies in...

OBJECTIVE To analyse the use of health care resources and the associated costs in patients with rheumatoid arthritis (RA) treated with three biological disease-modifying anti-rheumatic drugs (bDMARDs): etanercept, infliximab and adalimumab. METHOD DESIGN observational, retrospective, multicentre study. Length of study: 6 months. TARGET POPULATION patients with RA, who have been undergoin...

Results recently presented at the Annual refractory to them over time. Adalimumab Of those who had experienced no response European Congress of Rheumatology in Paris, France, suggests that adalimumab is safe and effective in patients with ankylosing spondylitis, rheumatoid arthritis and psoriatic arthritis who are not responding to anti-TNF therapy. In a recent series of studies, adalimumab was...

To the Editor: Adalimumab is an anti-tumor necrosis factor-alpha (TNF-α) monoclonal antibody that is widely used in autoimmune diseases including rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease and sarcoidosis. Paradoxically, sarcoidosis can develop during treatment with adalimumab. We report an unusual case of sarcoidosis after adalimumab therapy. A 25-year-old man wit...

We present a case of tuberculous peritonitis in a 46-year-old woman with rheumatoid arthritis treated with adalimumab, and we review the association between anti-tumour necrosis factor therapy and tuberculosis. This case illustrates that tuberculosis can develop with atypical clinic and uncertain laboratory findings and may mimic malignancies during adalimumab therapy.

Submit Manuscript | http://medcraveonline.com related cost has increased consistently [3]. At the moment, there are six biological agents licensed by FDA for the treatment of CD (infliximab, adalimumab, golimumab, certolizumab, vedolizumab, and natalizumab, the last two being an anti-α4β7 and anti-α4β1integrin, respectively), and three for UC (infliximab, adalimumab, and vedolizumab), whereas t...