Isoflurane, the most widely used inhalational anesthetic, releases inorganic fluoride during its metabolism by the cytochrome P450 system. Recent experimental data indicate that when cultured proximal tubular cells are exposed to inorganic fluoride, they become relatively resistant to myoglobin- and ATP depletion-mediated attack. The present study was undertaken to assess whether isoflurane ane...

INTRODUCTION Acute renal failure (ARF) has a poor prognosis in patients with cancer requiring intensive care unit (ICU) admission. Our aim is finding prognostic factors for hospital mortality in patients with cancer with ARF requiring renal replacement therapy (RRT). METHODS In this retrospective study, all patients with cancer with ARF treated with continuous venovenous filtration (CVVHDF) i...

Having recently described the injurious role of caspase-1-mediated production of the proinflammatory cytokine IL-18 in ischemic acute renal failure (ARF), we report here on the effect of the newly developed caspase inhibitor Quinoline-Val-Asp(Ome)-CH(2)-OPH (OPH-001) on caspase-1, IL-18, neutrophil infiltration, and renal function in ischemic ARF. C57BL/6 mice with ischemic ARF treated with OPH...

Dopamine use in acute renal failure (ARF) patients has been considered standard practice for many years. Despite this widely accepted practice, there has been limited evidence to support its usage. Low-dose dopamine has been accepted because it is considered to pose minimal risk to the patient. Dopamine infused at low doses is thought to be specific to dopaminergic receptors. However its result...

To elucidate the role of a proteasome-dependent proteolytic pathway in the pathogenesis of acute renal failure (ARF), we examined the effect of a selective proteasome inhibitor, lactacystin, on ARF induced by ischemia/reperfusion. Ischemic ARF was induced by clamping the left renal artery and vein for 45 min followed by reperfusion, 2 weeks after contralateral nephrectomy. Renal function in unt...

INTRODUCTION Tenofovir is a potent nucleotide analogue reverse-transcriptase inhibitor used with other antiretroviral agents for the treatment of human immunodeficiency virus (HIV) infection. Despite the absence of renal toxicity observed in the major clinical trials of tenofovir, several case reports of acute renal failure (ARF) and proximal tubule dysfunction have been described. CASE PRESE...

Acute renal failure (ARF) remains a significant cause of morbidity and mortality in adults and children. Although developing a treatment for ARF has been a challenge, there have been some advances in preventative strategies and supportive measures (1). Cell therapy, including the use of stem cells and progenitor INTRODUCTION �Received; March 25, 2013�Revised; May 22, 2013 �Accepted; June 25, 20...

The management of patients with acute renal failure (ARF) is very complex and requires meticulous attention to fluid, acid-base and electrolyte balance as well as the removal of uraemic toxins. Peritoneal dialysis (PD) is an important option for treatment of selected patients with ARF, particularly those who are haemodynamically compromised or have coagulation abnormalities. Due to continuous t...

We reported a 43-year-old woman who showed a Guillain-Barré like syndrome associated with acute renal failure (ARF) and thrombocytopenia following acute viral hepatitis A(HA). The clinical feature was acute progressive and of ascending symmetric paraparesis which developed 5 days after gastrointestinal infection. Neurologic examination showed flaccid paraparesis, areflexia in all extremities an...