Examining the dynamics of stroke ischemia is limited by the standard use of 2D-volume or voxel-based analysis techniques. Recently developed spatiotemporal models such as the 4D metamorphosis model showed promise for capturing ischemia dynamics. We used a 4D metamorphosis model to evaluate acute ischemic stroke lesion morphology from the acute diffusion-weighted imaging (DWI) to final T2-weight...

Atrial fibrillation (AF) commonly occurs in patient with acute myocardial infarction (AMI). Potential triggers for AF development in this setting includes reduced left ventricular function, advanced diastolic dysfunction and mitral regurgitation leading to elevated left atrial pressures and atrial stretch. Other triggering mechanisms include inflammation and atrial ischemia. Multiple studies ha...

background: impact of high level of uric acid on stroke is still controversial. we conducted this study to investigate the relationship between acute ischemic non-embolic stroke and serum levels of uric acid. methods: this was a case-control study on patients with acute ischemic non-embolic stroke in rafsanjan, iran. the control group consisted of normal persons who were similar to the case gro...

BACKGROUND AND PURPOSE Animal studies showed that human albumin therapy is strongly neuroprotective in focal ischemia. The aim of our study was to determine if relatively high serum albumin level is associated with decreased risk of poor outcome in ischemic stroke patients. METHODS Seven hundred fifty-nine consecutive patients with acute ischemic stroke were included. Functional outcome was m...

Introduction. Currently, despite the introduction of modern diagnostic algorithms in 20-40 % patients with ischemic stroke, it is not possible to establish its cause. Potential causes acute cerebral ischemia cryptogenic stroke include paroxysmal atrial fibrillation, patent foramen ovale, cardiomyopathy, carotid network, aortic arch atheroma, and cancer-associated thrombophilia. Target : systema...

background exertional heat stroke (ehs) is still a main cause of death in sport. many of ehs complications could have been prevented if ehs had been recognized and treated early and properly. case presentation we report an unusual case of multiple organ failure caused by ehs due to intensive sportive activities in a hot environment with lack of primary care. a 35-year-old healthy sportive man w...

OBJECTIVES Antiplatelet drugs are widely used for secondary prevention after cerebral ischemia of noncardioembolic origin and different antiplatelet drugs exert different pharmacologic effects. This study investigated differences in platelet activation markers in patients taking either aspirin or clopidogrel after acute ischemic stroke. METHODS A prospective randomized case-control study eval...

New edaravone derivatives containing a benzylpiperazine moiety are designed and synthesized. The structures characterized by 1 H NMR, 13 C high-resolution mass spectrometry. potential neuroprotective activities of the target compounds evaluated in differentiated rat pheochromocytoma cells (PC12 cells) mice subjected to acute cerebral ischemia. Most showed both vivo vitro, especially 1-(4-(4-flu...

Thromboxane B2 (TXB2) is the stable metabolite of thromboxane A2 (TXA2), a potent vasoconstrictor which induces irreversible platelet aggregation. The inhibition of TXA2 by aspirin and other agents has been associated with improved outcome following cerebral ischemia in clinical and laboratory studies. To investigate the relation of TXA2 production to cerebral ischemia, we measured the urinary ...

BACKGROUND AND PURPOSE Cervical artery dissection is a common cause of stroke in young people. The temporal profile of stroke risk after cervical artery dissection presenting without ischemia remains uncertain. METHODS We performed a crossover cohort study using administrative claims data on all emergency department visits and acute care hospitalizations from 2005 to 2011 in CA, 2006 to 2013 ...