nisms contributing to acute border zone infarctions. These include hemodynamic factors, embolic factors or both (1-6), and were determined by a transcranial Doppler (TCD) study and autopsies (7, 8). Before the era of magnetic resonance imaging (MRI), a computed tomography (CT) was the only method for diagnosing infarctions; however, due to limited resolution, subtle lesions caused by disseminat...

A 16 year boy was admitted with fever, headache, muscle pain, maculopapular rash and progressive altered sensorium. His serum dengue IgM was positive and was improving on conservative management. The patient developed right hemi paresis after 19 days and his MRI revealed multiple white mater lesions. He was diagnosed as acute disseminated encephalomyelitis (ADEM) following dengue hemorrhagic fe...

It is believed that viral infections and the hyperimmune reaction due to these infections are involved in the etiology of Kikuchi-Fujimoto Disease (KFD), a rare cause of fever of unknown origin. Axillary lymphadenopathy and neurologic involvement are rare in KFD. We present a patient diagnosed with KFD histopathologically during an investigation of the origin of fever and axillary lymphadenopat...

Disseminated mucormycosis endocarditis is extremely rare, and only a few cases have actually been reported in the literature. It is almost universally fatal despite aggressive surgical and medical management. In this article, we present the case of a 48-year-old immunocompromised male with mucormycosis endocarditis, who presented with acute bilateral lower extremity ischemia and passed away due...

We report a seven year old male with measles associated acute disseminated encephalomyelitis (ADEM) despite having received measles vaccination in infancy. The diagnosis was based on serum antimeasles antibodies and MRI brain. The patient was managed with high dose corticosteroids along with supportive measures. There was a complete neurologically and physica recovery.

Neurocysticercosis is the most common and preventable parasitic infection of the central nervous system, but disseminated cysticercosis is said to be rare. We report a case of a 31-year-old male, who presented with anxiety manifestations temporally associated with stress related to job. After initial clinical improvement, he presented with an incapacitating headache which was diagnosed as disse...

BACKGROUND Disseminated intravascular coagulation (DIC) after liver transplantation (LT) is a difficult complication. We report a case of disseminated intravascular coagulation after deceased donor liver transplantation (DDLT) treated with recombinant thrombomodulin (rTM). CASE PRESENTATION A 30-year-old woman underwent right tri-segment split graft DDLT for acute liver failure. She developed...

Acute disseminated encephalomyelitis (ADEM) is an uncommon monophasic idiopathic inflammatory demyelinating disease. Available diagnostic criteria do not reliably distinguish it from first presentations of relapsing diseases such as multiple sclerosis (MS) and neuromyelitis optica (NMO). In this article, we review current concepts about ADEM and what distinguishes it from other idiopathic infla...

Acute disseminated encephalomyelitis (ADEM) is an acute demyelinating infection of the CNS that is characterized by multifocal white matter involvement often following an infection and vaccination. A 16-year-old child receiving risperidone for 7 years for the treatment of attention-deficit/hyperactivity disorder was hospitalized with complaints of double-vision during the past month and weaknes...

We read with interest the case of dengue encephalopathy by Kanade and Shah1 and have the following comments to offer: The authors have correctly listed the three types of neurological manifestations associated with dengue infection1. We would like to add ‘acute disseminated encephalomyelitis’ (ADEM) to the list of post-infection neurological manifestation of dengue fever. ADEM is a monophasic, ...