The objective of the current study was to assess the separate and combined effects of marijuana and alcohol on actual driving performance. Eighteen subjects were treated with drugs and placebo according to a balanced, 6-way, crossover design. On separate evenings they were given weight calibrated Delta(9)-tetrahydrocannabinol (THC) doses of 0, 100 and 200 &mgr;g/kg with and without an alcohol d...

Computation is defining trait of biological systems and a broad framework that captures the complex adaptive nature of molecules, cells and organisms. Computation is also at the core of the genotype-phenotype mapping, since it provides a natural framework to define function in a self-consistent way. The study of existing biological systems (from signalling cascades to ant colonies or brains) as...

Self-centering rocking walls are known as viable alternatives to typical shear walls, as they provide a number of solutions for eliminating seismic flaws of conventional designs. These rocking walls have a generally positive impact on the seismic behavior of structural systems, but their design makes them susceptible to concrete crushing around their base, which can lead to significantly advers...

The redshift evolution of the galaxy cluster temperature function is a powerful probe of cosmology. However, its determination requires the measurement of redshifts for all clusters in a catalogue, which is likely to prove challenging for large catalogues expected from XMM-Newton, which may contain of the order of 2000 clusters with measurable temperatures, distributed around the sky. In this p...

Literature to date has demonstrated that producers and products spanning multiple categories have inferior market performance. However, two related but distinct explanations exist as to the source of such a discount. One explanation suggests that “actual” skills are degraded when producers attempt to engage across diverse categories. Another explanation involves perceptual fit to category repre...