نتایج جستجو برای: active bone formation

تعداد نتایج: 1210715  

2018
Debabrata Patra Elizabeth DeLassus Jennifer Mueller Grazia Abou-Ezzi Linda J Sandell

Site-1 protease (S1P) is a proprotein convertase with essential functions in the conversion of precursor proteins to their active form. In earlier studies, we demonstrated that S1P ablation in the chondrocyte lineage results in a drastic reduction in endochondral bone formation. To investigate the mechanistic contribution of S1P to bone development we ablated S1P in the osterix lineage in mice....

Journal: :Science signaling 2017
Shunsuke Uehara Nobuyuki Udagawa Hideyuki Mukai Akihiro Ishihara Kazuhiro Maeda Teruhito Yamashita Kohei Murakami Michiru Nishita Takashi Nakamura Shigeaki Kato Yasuhiro Minami Naoyuki Takahashi Yasuhiro Kobayashi

Cytoskeletal reorganization in osteoclasts to form actin rings is necessary for these cells to attach to bone and resorb bone matrices. We delineated the pathway through which Wnt5a signaling through receptor tyrosine kinase-like orphan receptor 2 (Ror2) promoted the bone-resorbing activity of osteoclasts. Wnt5a binding to Ror2 stimulated Rho, a small GTPase involved in cytoskeletal reorganizat...

2016
Yu-Ping Chen Ching-Yun Chen Cherng-Jyh Ke Yuan-Hung Chao Jui-Sheng Sun

Background: In patients who have sustained a traumatic brain injury with an associated extremity fracture there is often a clinical perception that the rate of new bone formation around the fracture site is increased. In this study, we made a rat model of femoral fracture to investigate the serum factors changes in vivo. We examined the effects serum factors on fracture healing and the molecula...

Journal: :International Archives of Otorhinolaryngology 2015

Journal: :The International journal of oral & maxillofacial implants 2001
K A Al Ruhaimi

This paper investigated the osteogenic potential of 6 osteoconductive grafting materials derived from human, bovine, and synthetic sources: HTR, BOP, Biogran, Laddec, Dembone, and Osteograf. Twenty-eight New Zealand rabbits were used in this study. The active group consisted of 24 animals and the control group consisted of 4 animals. The median condyle of each tibia was drilled with a 5-mm-diam...

پایان نامه :وزارت بهداشت، درمان و آموزش پزشکی - دانشگاه علوم پزشکی و خدمات بهداشتی درمانی مشهد - دانشکده دندانپزشکی 1394

جایگزینی دندان های از دست رفته به وسیله ایمپلنت دندانی به فراوانی انجام میشود. برای اینکه ایمپلنت به طور بهینه جایگزین شود باید در استخوان ایده ال جایگذاری شود که البته این نقایص قابل ترمیم هستند، یکی از این روشها guided bone regeneration است.

Journal: :The Journal of experimental biology 2005
Sander Kranenbarg Tim van Cleynenbreugel Henk Schipper Johan van Leeuwen

Mammalian bone is an active tissue in which osteoblasts and osteoclasts balance bone mass. This process of adaptive modelling and remodelling is probably regulated by strain-sensing osteocytes. Bone of advanced teleosts is acellular yet, despite the lack of osteocytes, it is capable of an adaptive response to physical stimuli. Strenuous exercise is known to induce lordosis. Lordosis is a ventra...

2014
Florence Lima Amr El-Husseini Marie-Claude Monier-Faugere Valentin David Hanna Mawad Darryl Quarles Hartmut H. Malluche

BACKGROUND Fibroblast growth factor-23 (FGF-23) is a hormone principally produced by osteocytes/osteoblasts. In patients with chronic kidney disease (CKD), FGF-23 levels are usually elevated and can reach up to 300 - 400 times the normal range. FGF-23 is regulated by local bone-related and systemic factors, but the relationship between circulating FGF-23 concentrations and bone remodeling and m...

Journal: :BMC Medical Physics 2009
Janaka Lenora Kristina Norrgren Ola Thorsson Per Wollmer Karl J Obrant Kaisa K Ivaska

BACKGROUND Skeletal uptake of 99mTc labelled methylene diphosphonate (99mTc-MDP) is used for producing images of pathological bone uptake due to its incorporation to the sites of active bone turnover. This study was done to validate bone turnover markers using total skeletal uptake (TSU) of 99mTc-MDP. METHODS 22 postmenopausal women (52-80 years) volunteered to participate. Scintigraphy was p...

Journal: :Polskie Archiwum Medycyny Wewnetrznej 2012
Teresa Gasińska Anna Borowska Hanna Wichary Renata Dec

INTRODUCTION  Immunosuppression with glucocorticoids is the method of choice in the treatment of active Graves' ophthalmopathy (GO). However, glucocorticoid therapy may have side effects, among others, it affects bone metabolism. OBJECTIVES  The aim of the study was to compare the effect of methylprednisolone pulse therapy (MPPT) with and without alendronate on bone turnover markers in patien...

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