An 80-year-old woman diagnosed with rheumatoid arthritis 22 years ago and with no other relevant medical or allergic conditions had been treated with methotrexate and prednisone for 2 years with good control of disease activity. In January 2007, methotrexate was stopped due to marked leukopenia, and treatment with intravenous infl iximab was started at a dose of 3 mg/kg every 2 weeks, with an a...

Actinic cheilitis is an oral potentially malignant disorder caused by UV radiation leading to damage epithelial keratinocytes of the lips. It predominantly affects vermillion border lower lip. Due its association with chronic exposure, associated risk factors include geographic areas, outdoor occupations, and skin subtypes. A high proportion lip squamous cell carcinomas arise from actinic lesio...

Actinic granuloma is a rare, idiopathic disorder of middleaged adults that always appears in sun-exposed skin [1,2]. It is a form of granulomatous dermatosis characterized by annular plaques with central atrophy and raised erythematous margins that are similar to those observed in granuloma annulare (GA) [3]. A 42-year-old man presented with a three-month history of an asymptomatic erythematous...

An under-recognized inflammatory dermatosis characterized by an evolution of distinctive clinicopathological features" (2016).

The penetration of solar H Lyman-α radiation into the terrestrial middle atmosphere is studied in detail. The Lyman-α actinic flux is calculated with a Monte Carlo approach including multiple resonance scattering of Lymanα photons within the terrestrial atmosphere and a temperature dependent absorption cross section of molecular oxygen. The dependence of the actinic flux on the temperature prof...