N europsychiatric symptoms, such as psychosis, are well described in Parkinson’s disease (PD); most appear to be due to disease pathology with exacerbation caused by dopaminergic treatment. More than 50% of patients with PD develop psychosis at some point throughout their disease course. Clinicians need to routinely assess patients with PD for psychotic symptoms, particularly hallucinations. Tr...

Involvement of the biogenic amines-acetylcholine, epinephrine, norepinephrine, dopamine, serotonin, and y-aminobutyric acid-in behavioral states through neurotransmission is appraised. An accessory role is favored for acetylcholine because its distribution and function in the brain are less specific than those of norepinephrine or serotonin, which are concerned with REM and deep sleep, while ep...

The breast cancer therapies available are insufficient, especially since first-line treatments, such as paclitaxel, result in drug resistance and their toxicity often limits concentration. Strategies like repurposing beneficial, novel treatments can emerge by drugs that interfere with the dopamine serotonin receptors, thus influence tumor growth. In this study, MTT assay was used to test effica...

The noncompetitive NMDA receptor antagonist phencyclidine (PCP) has psychotomimetic properties in humans and activates the frontal cortical dopamine innervation in rats, findings that have contributed to a hyperdopaminergic hypothesis of schizophrenia. In the present studies, the effects of the enantiomers of 3-amino-1-hydroxypyrrolid-2-one (HA966) on PCP-induced changes in monoamine metabolism...

in the present study, interactions of dopamine receptor agonists and antagonists with water swimming stress (wss) on naloxone-induced jumping in morphine-dependent mice were examined. mice were rendered dependent as described in the methods section. the opioid receptor antagonist, naloxone (1 mg/kg), was injected to elicit jumping (as a withdrawal sign). the first group exposed to wss in the pr...

Anxiety disorders and diabetes mellitus are one of the common psychiatric and endocrine disorders prevalent in general population, respectively1,2. The incidence and prevalence of anxiety disorders are very common in diabetic patients than in the general population3,4. In diabetic patients, recognition and control of psychiatry and anxiety symptoms are of utmost importance to increase complianc...

Relevance. Evaluation of the effect drugs on neurotransmitter processes is an important component pharmacodynamic studies. The quantitative determination monoamine neurotransmitters in brain structures laboratory animals urgent task pharmacology and physiology. Purpose study. Development a method for serotonin, dopamine, norepinephrine, histamine epinephrine rat homogenates using HPLC-MS/MS. Me...

Studies conducted with nonhuman laboratory animals have consistently shown that atypical antipsychotics that are mixed dopamine and serotonin antagonists attenuate the discriminative-stimulus effects of amphetamine. In the present experiment, eight healthy humans learned to discriminate 15 mg of oral d-amphetamine. After acquiring the discrimination (i.e., > or = 80% correct responding on four ...

Antipsychotic drugs have been classified as typical or atypical. To achieve an effective antipsychotic effect with typical antipsychotic drugs, e.g. haloperidol, a dopamine D2 receptor blockade of about 70% seems necessary. On the other hand, the prototype for atypical antipsychotic drugs clozapine is clinically effective already at about 45% D2 receptor occupancy. Clozapine possesses affinity ...