enzymes. Also, the problems of local circulation and capillary distribution were considered in relation to vulnerability of certain areas, i.e., Ammon's horn. The remaining three papers presented material concerned directly with pharmacological studies. These were: studies of the electrical activity of the brain in relation to anesthesia by Mary A. B. Brazier, the ascending reticular system and...

cellent s-donors. They readily form complexes with transition metals. Since 1990s, the use of NHCs as ligands has lead to significant advancements in the area of Pd-catalyzed carbon–carbon bond-forming reactions, Ru-catalyzed olefin metathesis, and Rh-catalyzed hydrosilylations. NHCs have also attracted significant attention as organocatalysts. Several reactions have been catalyzed by NHCs, for...

Engagement of the mast cell high-affinity receptor for immunoglobulin E (IgE), Fc«RI, induces tyrosine phosphorylation of Syk, a non-receptor tyrosine kinase, that has been demonstrated as critical for degranulation. Herein we describe a synthetic compound, ER-27319, as a potent and selective inhibitor of antigen or anti-IgE-mediated degranulation of rodent and human mast cells. ER-27319 affect...

In an attempt to find clinically useful modulators of multidrug resistance (MDR), a series of 19 N(10)-substituted-2-methoxyacridone analogues has been synthesized. 2-Methoxyacridone and its derivatives (1-19) were synthesized. Compound 1 was prepared by the Ullmann condensation of o-chlorobenzoic acid and p-anisidine followed by cyclization using polyphosphoric acid. This compound undergoes N-...

The gene that codes for human growth hormone (hGH) is used as a reporter gene to assess changes an effector may have on gene expression of a specific DNA sequence (6). hGH is secreted into the medium of transfected cells following the addition of an appropriate effector; measurement of hGH levels allows for quantification of the degree of activation (or suppression) of gene expression relative ...

Joseph J. Magadula*, Ester Innocent, Zakaria H. Mbwambo and Modest C. Kapingu Institute of Traditional Medicine, Muhimbili University of Health and Allied Sciences, P. O. Box 65001, Dar es Salaam, Tanzania *Corresponding author International Journal of Current Research and Academic Review ISSN: 2347-3215 Volume 2 Number 10 (October-2014) pp. 99-111 www.ijcrar.com Int.J.Curr.Res.Aca.Rev.2014; 2(...

Open AccessCCS ChemistryRESEARCH ARTICLE1 Feb 2021Macrocyclic Nonapeptides Incorporating Uncharacterized Amino Acids with Inhibitory Effects on Th17 Differentiation Kai-Long Ji, Yao-Yue Fan, Hio-Ha Kuok, Qun-Fang Liu, Ting Li and Jian-Min Yue Ji State Key Laboratory of Drug Research, Shanghai Institute Materia Medica, Chinese Academy Sciences, 201203 Google Scholar More articles by this author ...