نتایج جستجو برای: acpa

تعداد نتایج: 903  

2011
Saedis Saevarsdottir Bo Ding Kristjan Steinsson Gerdur Grondal Helgi Valdimarsson Lars Alfredsson Lars Klareskog Leonid Padyukov

INTRODUCTION Previous studies have provided inconsistent results on whether variants in the MBL2 gene, coding for the complement-activating mannan-binding lectin (MBL) protein, associate with rheumatoid arthritis (RA). We re-evaluated this in context of the main environmental and genetic risk factors (smoking, HLA-DRB1 'shared epitope' (SE), PTPN22*620W), which predispose to rheumatoid factor (...

Journal: :RMD open 2016
G Akdemir I M Markusse L Dirven N Riyazi G M Steup-Beekman Pjsm Kerstens W F Lems Twj Huizinga C F Allaart

OBJECTIVE To determine the most effective treatment strategy among anticitrullinated protein antibodies (ACPA)-negative patients with early rheumatoid arthritis. METHODS In the BeSt study, 184 ACPA-negative patients were randomised to: (1) sequential monotherapy, (2) step-up therapy, (3) initial combination including prednisone, (4) initial combination including infliximab. Treatment was targ...

2017
Marije K. Verheul Michel P. M. Vierboom Bert A. ’t Hart Rene E. M. Toes Leendert A. Trouw

BACKGROUND Rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPA) and anti-carbamylated protein (anti-CarP) antibodies are rheumatoid arthritis (RA)-associated autoantibodies. Besides their presence in human serum, anti-CarP antibodies have also been described in rodent models of arthritis, while ACPA are not consistently detectable. Data on these RA-associated autoantibodies in p...

Journal: :Arthritis and rheumatism 2013
Thomas Frisell Marie Holmqvist Henrik Källberg Lars Klareskog Lars Alfredsson Johan Askling

OBJECTIVE To estimate familial aggregation of rheumatoid arthritis (RA) in 3 large population-representative samples and to test if familial aggregation is affected by rheumatoid factor (RF)/anti-citrullinated protein antibody (ACPA) status, type of relative, sex, and age at onset of RA. METHODS A register-based nested case-control study was performed in the Swedish total population. Data on ...

2015
Cátia Fernandes-Cerqueira Elena Ossipova Sunithi Gunasekera Monika Hansson Linda Mathsson Anca I. Catrina Yngve Sommarin Lars Klareskog Karin Lundberg Johan Rönnelid Ulf Göransson Per-Johan Jakobsson

INTRODUCTION We have previously identified endogenously citrullinated peptides derived from fibrinogen in rheumatoid arthritis (RA) synovial tissues. In this study, we have investigated the auto-antigenicity of four of those citrullinated peptides, and explored their feasibility to target anti-citrullinated protein/peptide antibodies (ACPA). METHODS The autoantigenic potential of the fibrinog...

2017
Elena Rykova Aleksey Sizikov Dirk Roggenbuck Oksana Antonenko Leonid Bryzgalov Evgeniy Morozkin Kseniya Skvortsova Valentin Vlassov Pavel Laktionov Vladimir Kozlov

BACKGROUND Early diagnosis of rheumatoid arthritis (RA) is crucial to providing effective therapy and often hampered by unspecific clinical manifestations. Elevated levels of extracellular circulating DNA (cirDNA) in patients with autoimmune disease were found to be associated with etiopathogenesis. To our knowledge, this is the first study to investigate the putative diagnostic use of cirDNA i...

Journal: :Annals of the rheumatic diseases 2015
J Suurmond F Rivellese A L Dorjée A M Bakker Y J P C Rombouts T Rispens G Wolbink A Zaldumbide R C Hoeben T W J Huizinga R E M Toes

OBJECTIVE Mast cells may play a role in rheumatoid arthritis (RA), but activation of human mast cells in autoimmune settings has been little studied. Toll-like receptors (TLR) and Fcγ receptors (FcγR) are important receptors for cellular activation in the joint, but expression and stimulation of these receptors in human mast cells or the functional interplay between these pathways is poorly und...

Journal: :Genetics 1996
S L Allen D Zeilinger E Orias

We demonstrate a reliable method for mapping conventional loci and obtaining meiotic linkage data for the ciliated protozoan Tetrahymena thermophila. By coupling nullisomic deletion mapping with meiotic linkage mapping, loci known to be located on a particular chromosome or chromosome arm can be tested for recombination. This approach has been used to map three isozyme loci, EstA (Esterase A), ...

Journal: :The Journal of biological chemistry 2006
Richard L Felts Thomas J Reilly John J Tanner

AcpA is a respiratory burst-inhibiting acid phosphatase from the Centers for Disease Control and Prevention Category A bioterrorism agent Francisella tularensis and prototype of a superfamily of acid phosphatases and phospholipases C. We report the 1.75-A resolution crystal structure of AcpA complexed with the inhibitor orthovanadate, which is the first structure of any F. tularensis protein an...

Journal: :Revista brasileira de reumatologia 2011
Magali Justina Gómez Usnayo Luis Eduardo Coelho Andrade Renata Triguenho Alarcon Juliana Cardoso Oliveira Gustavo Milson Fabrício Silva Izidro Bendet Rufus Burlingame Luis Cristóvão Porto Geraldo da Rocha Castelar Pinheiro

UNLABELLED The HLA-DRB1 alleles encoding an amino acid sequence (QKRAA/QRRAA/RRRAA) at position 70 74 of the third hypervariable region of the β1 chain of the HLA-DRB1 gene, called shared epitope (SE), are associated with increased susceptibility to and severity of rheumatoid arthritis (RA) in different populations. OBJECTIVE To determine the frequency of HLA-DRB1 alleles in Brazilian patient...

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