Biologic drugs have provided excellent results in the treatment of moderate to severe psoriasis. Nevertheless, in routine clinical practice, combinations of biologic drugs with phototherapy or systemic drugs can increase efficacy, diminish toxicity, and reduce the cost of treatment. Published experience with these combinations is scarce, although the results are often satisfactory. This review ...

A 63-year-old fisherman presented for a chronic and progressive eruption, beginning on his right hand extending up arm over the past 8 years. He reported that he spent time in forests handled raw fish without gloves frequently; also recalled an inoculation injury while forest. The patient denied previous exposure to halogens. On examination, had multiple edematous verrucous plaques with crust e...

Lichen planus (LP) is a chronic autoimmune inflammatory dermatosis that is characterized by purple, pruritic plain topped papules, involving the skin, mucous membrane, nail and hair follicles. According to the site of involvement there are various forms of LP. Palmoplantar LP is one of the rare clinical variants, which is meanwhile accompanied with the oral involvement being extremely uncommon....

GJB2: gap junction protein b2 KID: keratitis-ichthyosis-deafness INTRODUCTION Keratitis-ichthyosis-deafness (KID) syndrome is a rare genodermatosis with approximately 100 published cases. Although it is classified as an autosomal dominant disorder, more than 90% of cases are caused by sporadic mutations predominantly in gap junction protein b2 (GJB2) on chromosome 13q11-q12 (OMIM 148210). GJB2 ...

Treatment of pityriasis rubra pilaris is still challenging. We here present a 74-year-old woman who had not experienced stable remission of her skin symptoms during prior treatments including topical and systemic corticosteroids, phototherapy, orally administered acitretin, cyclosporine, methotrexate and adalimumab. A therapy with oral alitretinoin was started and tolerated very well. After a f...