INTRODUCTION Carbapenem-resistant Acinetobacter baumannii (CRAB) infection is being increasingly observed and is associated with significant morbidity and mortality in newborns. In this study, we determined the epidemiology, risk factors, and outcomes of blood stream infection (BSI) caused by CRAB in neonates. METHODOLOGY The clinical charts of neonates who developed Acinetobacter baumannii B...

background the treatment of acinetobacter baumannii infections is difficult. carbapenems, sulbactam, and colistin are the most effective antibiotics. objectives the aim of this study was to evaluate the susceptibilities of genotypically different a. baumannii isolates to sulbactam, amikacin, netilmicin, meropenem, tigecycline and colistin. patients and methods isolates from various clinical sam...

The Acinetobacter baumannii clonal complex 113/79 (CC113/79) and class 2 integrons predominate in Latin America; a relationship between these characteristics was explored. The presence of integrases was determined in successive hospital Acinetobacter isolates (163 A. baumannii isolates and 72 Acinetobacter nosocomialis isolates). Most isolates had integrons, but class 1 and 2 integrons were pre...

Invasive disease due to Acinetobacter baumannii is an increasing problem in health care settings worldwide. Whether certain clones of A. baumannii are more likely to cause invasive disease in hospitalized patients is unknown. We studied all patients at a public teaching hospital in Houston, Texas, from whom the Acinetobacter calcoaceticus-Acinetobacter baumannii complex was isolated over a 14-m...

BACKGROUND Mediastinitis resulting from surgical site infection may occur in 1% of patients undergoing median sternotomy. METHODS Case report and review of the pertinent English-language literature. RESULTS We report a case of mediastinitis caused by Acinetobacter baumannii, in a patient with multiple comorbidities who underwent cardiopulmonary bypass. Successful treatment consisted of surg...

Multidrug-resistant Acinetobacter baumannii is one of the most important pathogens in intensive care units related to morbidity and mortality. Colistin is being used increasingly as “salvage” therapy for these patients. However, resistance to colistin in A. baumannii has recently been reported. We herein present a case in which ventilator-associated pneumonia due to A. baumannii developed in on...

Insertion sequence (IS) elements are important mediators of genome plasticity and can lead to phenotypic changes with evolutionary significance. In multidrug-resistant Acinetobacter baumannii and Klebsiella pneumoniae, IS elements have contributed significantly to the mobilization of genes that encode resistance to antimicrobial drugs. A systematic analysis of IS elements is needed for a more c...

A review of the literature was undertaken to delineate the current level and mechanisms of resistance to carbapenems, colistin, and tigecycline in South Africa. Thirty-two English publications and 32 National Institute of Communicable Diseases communiqués identified between early January 2000 and 20 May, 2016 showed substantial reports of NDM (n = 860), OXA-48 (n = 584), VIM (n = 131), and IMP ...

The first step in the biofilm formation is the bacterial attachment to solid surfaces, which is dependent on the bacteria cell surface physico-chemical properties. The purpose of this work was to analyze the effect of pH on the physicochemical cell surface properties of Acinetobacter baumannii by two different methods. The cell surface properties were evaluated using the microbial adhesion to s...