An application of readily available hydrazides in the Petasis 3-component coupling reaction is presented. An investigation of the substrate scope was performed to establish a general, synthetically useful protocol for the formation of hydrazido alcohols, which were selectively converted to oxazolidinone and oxadiazolone ring systems through triphosgene-mediated cyclization reactions.

There has been considerable interest in the development of novel compounds with anticonvulsant, antioxidant, antibacterial, and antifungal activities. The present study explores antimicrobial activity some new arylidene hydrazide derivatives correlates effect on potency by varying substituents part arylidine hydrazide. Hydrazones possessing an azomethine–NHN=CH- proton constitute important clas...

In the title compound, C(7)H(8)N(2)O(2), the mean planes of the benzene ring and the planar hydrazide group are inclined at 25.75 (6)° with respect to each other. The structure is stabilized by inter-molecular N-H⋯O and O-H⋯N hydrogen bonds.

Enhancing the efficiency and maneuverability of organic synthesis constitutes one of the most exciting challenges to synthetic chemists. Within the last decade, green chemistry has attained the status of a major scientific discipline. The investigation and application of green chemistry principles has led to the development of cleaner and more benign chemical processes, with many new technologi...

Diclofenac sodium has been used for its anti-inflammatory actions for about 28 years, but since all the non-steroidal anti-inflammatory drugs (NSAIDs) suffer from the lethal gastro intestinal (GI) toxicities, diclofenac sodium is not an exception. The free –COOH group is thought to be responsible for the GI toxicity associated with all traditional NSAIDs. In the present research, the main motto...

BACKGROUND Taking into account the improvement in insecticidal activity by the inclusion of fluorine in the hydrazone moiety, the authors synthesized new 4-fluorobenzoic acid hydrazides and 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazoles, substituting a phenyl group or a heteroaryl ring carrying one or two atoms of F, Cl and Br, and investigated their biting deterrent and larvicidal ac...

Like beads on a string: A synthetic method for the directional construction of strings of spherical fullerenes along stacks of planar oligothiophenes is described. The key to success was the preparation of fullerenes with two solubilizing tri(ethylene glycol) tails (bold) and an aromatic aldehyde for covalent capture by hydrazides along the oligothiophene stacks (red). BOLAG, Alatengbaolige, et...

The present position regarding the treatment of tuberculous meningitis in childhood is that parents can be offered a go per cent. chance of complete recovery. This transformation is due to the introduction of streptomycin and isonicotinic acid hydrazide. Whereas streptomycin first changed a uniformly fatal disease to one with a mortality of 70 per cent., isoniazid has made it possible to press ...