Relative bioavailability and toxicity of N-acetyl-l-Cys (NAC) were evaluated in 9-d chick growth assays. The bioavailability of NAC relative to Cys was determined by feeding young chicks a highly purified crystalline AA diet singly deficient in Cys. Bio-availability estimates were obtained using standard slope-ratio methodology. N-Acetyl-l-cysteine was shown to be as effective as Cys in support...

BACKGROUND Use of mucolytic agents that result in reduced mucous viscosity of the gastric mucous has been suggested to have an additive effect in curing Helicobacter pylori infection. METHODS Seventy Hpylori-positive patients were given either eradication treatment consisting of 500 mg clarithromycin bid and 30 mg lansoprazole bid for 10 days plus 10 mL (400 mg) N-acetyl cysteine (NAC) liquid...

Effect of N-acetyl cysteine on thiol levels We read with interest the article by Dr Bridge-man and colleagues on the effect of oral N-acetyl cysteine (NAC) on thiol levels in epithelial lining fluid (ELF) and lung tissue (July 1994;49:670-5). Their suggestion that NAC may not be the drug of choice to enhance the glutathione antioxidant potential of the lungs in chronic obstructive pulmonary dis...

Lack of cytocompatibility in bone substitutes impairs healing in surrounding bone. Adverse biological events around biomaterials may be associated with oxidative stress. We hypothesized that a clinically used inorganic bone substitute is cytotoxic to osteoblasts due to oxidative stress and that N-acetyl cysteine (NAC), an antioxidant amino acid derivative, would detoxify such material. Only 20%...

Citation: The PLOS ONE Staff (2014) Correction: Efficacy of N-Acetyl Cysteine in Traumatic Brain Injury. PLoS ONE 9(7): e104353. doi:10.1371/journal.pone.0104353 Published July 28, 2014 Copyright: 2014 The PLOS ONE Staff. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any m...

In the present study, we examined the effect of N-acetyl-L-cysteine (NAC), a glutamate-modulating agent, on marble-burying behavior in mice. Fluvoxamine (30 mg/kg, p.o.) and mirtazapine (3 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. Similarity, NAC (150 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor...

  Objective- Mechanisms that decrease oxidative stress and enhance peritoneal fibrinolysis reduce adhesions. N-acetyl-L-cysteine (NAC) is an antioxidant whose effect on peritoneal fibrinolysis in large animal model has not been established. The aims of this study were to investigate the ability of NAC to decreased adhesion in stablished model of serosal trauma in sheep. Design- Expe...

Objective Chlorpyrifos (CPF), an organophosphate pesticide, is widely used in farms in order to preserve crops and fruits. Previous studies have shown that CPF exposure might cause chronic toxicity in male genital system. The present study investigated the protective effect of N- Acetyl Cysteine (NAC), a potent antioxidant against toxicity effect of CPF in male mice. MaterialsAndMethods in an e...

background: fatalities from acetaminophen poisoning are common, but they are preventable by timely treatment with n-acetyl cysteine (nac). in many medical centers, nac is prescribed in keeping with the ingested dose of the drug as revealed through medical history. it seems to significantly differ from the real indications of nac administration based on plasma level of acetaminophen. overtreatme...

This study evaluated the efficacy of penicillin in improving culture yield M. Tuberculosis cases pulmonary tuberculosis. A retrospective was conducted Department Pathology, MMDC, Multan. total 350 suspected tuberculosis patients were selected for study. An early morning sputum specimen collected. NAOH citrate and N-acetyl-L-cysteine used digesting, decontaminating, homogenizing sputum. The samp...