Neroe endings and deposits of cholinesterase were stained in frozen sections of five normal striated human eye muscles with a stain that combines the neroe fiber techniijue of Hortega and the method of Koelle and Friedenwald for the demonstration of cholinesterase. Cholinesterase deposits are found at the base of the motor end plates. Dense cholinesterase deposits can also he found around thin ...

As an extension of previous investigations (1, 2) concerning the specificity of cholinesterase, the present study deals with the effect upon enzymatic hydrolysis of variations in the chain length of the acid component of choline esters. It is known from earlier work (3, 1) that increasing the normal chain length from 2 to 4 carbon atoms results in increased cnzymatic and decreased alkaline spli...

Cholinesterase inhibitors are the 'first-line' agents in the treatment of Alzheimer's disease. This article presents the latest information on their pharmacokinetic properties and pharmacodynamic activity. Tacrine was the first cholinesterase inhibitor approved by regulatory agencies, followed by donepezil, rivastigmine and recently galantamine. With the exception of low doses of tacrine, the c...

The importance of Hypericum L. species, being used in traditional medicine, the scientific world is increasing day by day. species are plants that have been treatment many diseases for a long time and healing properties. In current study, essential oil compositions scabrum H. ternatum Poulter collected from different localities Turkey were determined GC-MS/FID. addition, their antioxidant, cyto...

INTRODUCTION Down syndrome (DS) children have different degrees of developmental abnormalities associated with mental retardation. A cascade of pathological changes triggering alterations in cholinesterase-mediated functions seems to be the cause of neuronal and muscular dysfunctions, such as memory loss, disturbed cognitive skills, and language impairment in virtually all DS individuals, but t...

The present study was undertaken to identify the nature of the interactive effects of chlorpyrifos (CPF) and cold stress (15 degrees and 20 degrees C) on the activities of acetyl cholinesterase (AChE), choline acetyl transferase (ChAT), Na+, K(+)-ATPase and malondialdehyde (MDA) level in the cerebral cortex of 1 week, 3 weeks and 3 months of age. The results indicated an interaction of CPF with...

2-Isopropyl-4-dimethylamino-5-methylphenyl-1-piperidine carboxylate methyl chloride (AMO-1618) inhibits the activity of a cholinesterase isolated from mung bean (Phaseolus aureus) roots at concentrations comparable to those which retard growth and inhibit development of secondary roots of bean seedlings. Fifty per cent inhibition of the cholinesterase activity occurred at 0.21 mm. Inhibition of...

Cholinesterase Activity in Female Greenhouse Workers—Influence of Work Practices and Use of Oral Contraceptives: Jesper B NIELSEN, et al. Environmental Medicine, University of Southern Denmark—Objectives—Associations between serum butyryl cholinesterase activity in female greenhouse workers and information from a questionnaire on work, use of personal protective equipment, and lifestyle were ev...

People with genetic variants of cholinesterase respond abnormally to succinylcholine, experiencing substantial prolongation of muscle paralysis with apnea rather than the usual 2-6 min. The structure of usual cholinesterase has been determined including the complete amino acid and nucleotide sequence. This has allowed identification of altered amino acids and nucleotides. The variant most frequ...