The pharmacokinetics of alprazolam (ALP) after i.v. and p.o. administration in rats were characterized. ALP decayed biexponentially after the i.v. dose (1.25 mg/kg), but the concentration-time profiles after the p.o. doses (7 and 12.5 mg/kg) exhibited a doublepeak phenomenon. The presence of two peaks was confirmed by statistical analysis of the serum concentration data of ALP, as well as by ob...

Developing adaptive personalized eLearning has proven to be quite expensive regarding time and cost. Typical adaptive course creation requires input from subject matter experts, pedagogical experts and technical experts. This paper describes a framework for developing adaptive personalized pedagogically sound courses in a developer-supported environment. The paper describes the Adaptive Course ...