Purpose: To evaluate the α-glucosidase inhibitory activity of Croton bonplandianum Baill as a probable remedy for the management of diabetes. Methods: Dichloromethane and methanol extracts were prepared and screened for their α-glucosidae inhibitory activity using standard in vitro α-glucosidae inhibition assay. Acarbose was used as positive control. Results: α-Glucosidae inhibition activity of...

The objective of the present study was to evaluate the inhibitory properties of various extracts of propolis on alpha-glucosidase from baker's yeast and mammalian intestine. Inhibitory activities of aqueous ethanol extracts of propolis were determined by using 4-nitrophenyl-D-glucopyranoside, sucrose and maltose as substrates, and acarbose as a positive reference. All extracts were significantl...

In vitro study revealed that pancreatic lipase inhibitory activity of C. asiatica extract was significantly higher than rutin but lower than orlistat, an anti-obesity drug. alpha-Amylase inhibitory activities of C. asiatica extract and rutin were significantly lower than acarbose, an anti-diabetic drug. Inhibition of alpha-glucosidase activity by C. asiatica extract, rutin, and acarbose was not...

Introduction: The term “reactive” hypoglycemia, also known as post-prandial hypoglycemia has been loosely defined in the literature. The term refers to the occurrence of autonomic symptoms including weakness, perspiration, hunger, nausea, anxiety and tremors occurring one to two hours after ingestion of a meal. This collection of symptoms has been described in various patient groups including p...

garlic (allium sativum l., alliaceae), persian shallot (allium ascalonicum l., alliaceae ) and sage (salvia officinalis l., lamiaceae) are believed to have hypoglycemic properties and have been used traditionally as antidiabetic herbal medicines in iran. in this study, diabetes was induced by subcutaneous injection of alloxan monohydrate (100 mg kg−1) to male wistar rats. antidiabetic effects of...

The crystal structure of Bacillus subtilis -amylase, in complex with the pseudotetrasaccharide inhibitor acarbose, revealed an hexasaccharide in the active site as a result of transglycosylation. After comparison with the known structure of the catalytic-site mutant complexed with the native substrate maltopentaose, it is suggested that the present structure represents a mimic intermediate in t...