The glycopeptide vancomycin has an antimicrobial effect by halting the synthesis of bacterial cell-wall binding D-Ala-D-Ala peptide motif precursor Lipid II. This interaction been extensively investigated using techniques such as XRD and NMR. Here, complexed with Ala-γGlu-Lys-D-Ala-D-Ala (the pentapeptide part II) is studied means Raman optical activity (ROA) spectroscopy. Where for conventiona...

The delta-amino acid 5-aminolevulinic (ALA), is the precursor of endogenous photosensitiser Protoporphyrin IX (PpIX), and currently approved for Photodynamic Therapy (PDT) certain superficial cancers. However, ALA-PDT not very effective in diseases which T-cells play a significant role. Cutaneous T-cell lymphomas (CTCL) group non-Hodgkin malignant diseases, includes mycosis fungoides (MF) Sézar...

introduction: the use of lopinavir/ritonavir (lpv/r) has decreased morbidity and mortality due to human immunodeficiency virus (hiv); however its use could be impaired by hepatotoxicity. therefore, this study was designed to investigate the effects of melatonin (mt) and alpha lipoic acid (ala) on lpv/r-induced hepatotoxicity in male albino rats. methods: rats were divided into groups and treate...

introduction: this study evaluated the effects of pretreatments with melatonin (mt), and alpha lipoic acid (ala) on lopinavir/ritonavir (lpv/r) -induced serum levels of creatinine (cr), urea (u), uric acid (ua) and kidney levels of malondialdehyde (mda), superoxide dismutase (sod), glutathione (gsh) and catalase (cat) in male albino rats. effects of treatments with mt and ala were also evaluate...

Oomen et al (1) reported on the lack of association between -linolenic acid (ALA, 18:3n 3) consumption and the incidence of coronary artery disease in a 10-y follow-up. We believe that 2 major limitations of this study might have affected its outcome and led to the wrong conclusions. First, this study did not control for plasma concentrations of -linolenic acid; it is thus difficult to establis...

A RAPID and accurate diagnosis of acute intermittent porp11yri t ( AlP) became possible once suitable methods were available for measurement of urine content of -aminolevulinic acid ( AI A ) and porphobilinogen (PBG).”2 Similarly, in lead poisoning, determination of ALA excretion has proven a useful chemical adjunct, both for diagnostic and therapeutic evaluation.3 The biochemical defect( s ) w...