Abnormal embryonic development is a complication of the diabetic pregnancy, and heart defects are among the most common and detrimental congenital malformations of the diabetic embryopathy. Hypoglycemia is a common side effect of diabetes therapy and is a potential teratogen. An association between hypoglycemia and congenital defects has been difficult to demonstrate in humans, but in vivo and ...

Background: Environmental pollutants including organophosphate insecticides impair glucose metabolism by altering hepatic oxidation and play an important role in the development of diabetes and its complications. The aim of this study was to assess the impacts of repeated oral doses of Diazinon, an organophosphate insecticide, which is known to impair the glucose metabolism and its tolerance th...

This paper will focus on the use of nicotinic acid as a therapeutic option for cardiovascular risk reduction in patients with abnormal glucose metabolism and ‘atherogenic dyslipidaemia’. This is characterised by low levels of HDL-C, high triglycerides, and preponderance of small, dense LDL particles. Whilst nicotinic acid may increase plasma glucose in some patients, more recent studies show th...

Study of EMS cases has revealed several measurable plasma analytes that serve as markers for dysregulation of glucose and lipid metabolism that culminates in increased laminitis susceptibility. Although the exact pathophysiologic pathways leading to laminitis have not been elucidated, it is likely that some of these analytes may have direct pathologic relevance whilst others simply act as indir...

The frequency of carpal tunnel syndrome (CTS) is increased in patients with peripheral neuropathy from a variety of causes (1). Abnormal glucose metabolism may be implicated in the etiology of “idiopathic” polyneuropathy in subjects who do not have diabetes (2). We investigated whether the incidence of CTS, Bell’s palsy, and other peripheral nerve disorders is increased before the diagnosis of ...

Betatrophin is a member of the angiopoietin-like (ANGPTL) family that has been implicated in both triglyceride and glucose metabolism. The physiological functions and molecular targets of this protein remain largely unknown; hence, a purified available protein would aid study of the exact role of betatrophin in lipid or glucose metabolism. In this study, we cloned the full-length cDNA of betatr...