The Reed-Sternberg (RS) cell is the driving force behind Hodgkin lymphoma (HL), a unique malignancy in which the rare RS cell creates an inflammatory microenvironment that recruits a reactive tumor infiltrate. Well-known oncogenic factors such as nuclear factor kappa B (NFκB) signaling and Epstein-Barr virus infection are linked to HL pathogenesis but do not adequately explain the RS cell's key...

The two-dimensional Principal Component Analysis (2DPCA) is a robust method in face recognition. Much recent research shows that the 2DPCA is more reliable than the well-known PCA method in recognising human face. However, in many cases, this method tends to be overfitted to sample data. In this paper, we proposed a novel method named random subspace two-dimensional PCA (RS-2DPCA), which combin...

Objective: To determine the initial mechanical stabilization of conventional glass ionomer cements (GICs) indicated for atraumatic restorative treatment (ART) in different storage periods. Material and Methods: Specimens were divided according to GIC (n=12): IZ - Ion-Z, KM Ketac Molar Easymix, RS Riva Self Cure, GL Gold Label 9. They prepared stored distilled water. Superficial microhardness (S...

Mouse hybridomas producing antibodies against the structural proteins of strain WV4843, a subgroup B strain of respiratory syncytial (RS) virus, were produced by fusion of Sp2/0 myeloma cells with spleen cells from BALB/c mice immunized with purified preparations of the virus. After immunoprecipitation test with [35S]methionine-labelled extracellular virions, 35 clones found to produce antibodi...

Comment on: Constitutive activation of DNA damage response pathway as a novel therapeutic target in diffuse large B-cell lym-phoma. Derenzini et al. There is now significant evidence indicating that replication stress (RS) is prevalent in human cancers and that it is induced by the constitutively activated oncogenes that are driving cancer cell proliferation [1]. The collapsed replication forks...

The two Abelson murine leukemia virus (A-MuLV)-transformed cell lines, BM18-4 and ABC-1, undergo immunoglobulin L-chain gene recombination during passage in tissue culture. BM18-4 cells are capable of kappa gene recombination, whereas ABC-1 cells are capable of both kappa and lambda gene recombination. The expression of H chains is apparently not necessary for continuing L chain gene recombinat...