The aim of this study was to assess the value of 99mTc-hexakis-2-methoxyisobutylisonitrile (MIBI) scintigraphy in patients with clinical and radiologic features of primary or metastatic musculoskeletal tumors. Methods: The scintigraphic findings for 84 patients were compared with the surgical and histologic findings. Each patient underwent three-phase bone scan with 99mTc-methylene diphos...

Receptors for somatostatin (SST) (SSTR) are expressed on various tumor cells as well as on activated lymphocytes. Previous data have shown that 99mTc-P829 binds with high affinity to many different types of tumor cells as well as to leukocytes via the human hSSTR2, hSSTR3, and hSSTR5 target receptors. Consequently, 99mTc-P829 was successfully introduced as a peptide tracer for tumor imaging. In...

UNLABELLED 99mTc-methoxyisobutylisonitrile (99mTc-MIBI) has been suggested as a tracer for the scintigraphic detection of multidrug resistance (MDR). The aim of this study was to compare MDR characteristics in vitro and in vivo by immunohistochemic and functional uptake assays in established tumor cell lines cultured and grown in severe combined immunodeficient (SCID) mice. METHODS The presen...

In this issue of The Journal of Nuclear Medicine, Gabriel et al. (1) report their experience with 68Ga-labeled 1,4,7,10tetraazacyclododecane-N,N9,N99,N999tetraacetic acid-D-Phe1-Tyr3-octreotide (68Ga-DOTA-TOC) PET in a series of 84 patients with neuroendocrine tumors (NET). PET was more accurate with a higher detection rate than somatostatin receptor scintigraphy (using 111In-DOTA-TOC or 99mTc-...