Transarterial radioembolization (TARE) effectively treats unresectable primary and metastatic liver tumors through intra-arterial injection of Yttrium-90 (90Y) beta particle emitting microspheres which implant around the tumor. Current dosimetry models are highly simplistic there is a large need for an image-based post-TARE, would improve treatment safety efficacy. post-TARE imaging 90Y bremsst...

Antibody-based therapies, both unconjugated antibodies and radioimmunotherapy, have had a significant impact on the treatment of non-Hodgkin lymphoma. Single-agent rituximab is an effective therapy, but it is being increasingly used with combination chemotherapy to improve the objective response and its duration. The approved anti-CD20 radioimmunoconjugates (90Y-ibritumomab tiuxetan or 131I-tos...

Methods of single-tracer whole-body autoradiography (WBAR) have been developed in our laboratory which allow imaging and measurement of the zonal distribution of radioiodinated antibodies and their fragments within GW-39 colon carcinoma xenografts varying in size from large, cystic masses with necrotic cores to micrometastases. The whole-animal distribution of 90Y-labeled anti-carcinoembryonic ...

The two radionuclides most commonly used for intra-articular therapy are '98Au and 90Y. Both emit #-radiation, which is absorbed within a small distance from the site ofemission in tissue. The decay of 198Au is also accompanied by y-radiation, which can be detected from outside the body using a scintillation detector. 90Y, however, has no y-emission, but its presence can be detected from outsid...

Two yttrium-90 (90Y) radiosynovectomy procedures were compared. One procedure, performed at the Royal Perth Rehabilitation Hospital (RPRH) required a shorter immobilisation time than that performed at the Sir Charles Gardiner Hospital (SCGH). There were no significant differences in outcome between the two procedures for the groups with inflammatory and osteoarthropathy. Thirty two patients (45...

Several groups are developing ultra-miniature x-ray machines for clinical use in radiation therapy. Current systems are for interstitial radiosurgery and for intravascular insertion for irradiation to prevent re-stenosis. Typical generating voltages are low, in the 20 to 40 kV range. It is well established that the biological effectiveness of such low-energy photons is large compared with highe...

A long-term in situ subsurface instrument for monitoring radioactive contaminant plumes, as an alternative to soil analysis, is described. A portable, laser-based reader optically stimulates luminescence from sensors, each containing an Al2O3:C dosemeter. The sensors, designed for placement at various subsurface locations around a waste site, are allowed to accumulate dose for a predetermined t...