نتایج جستجو برای: 9 mmp

تعداد نتایج: 492520  

Journal: :Arthritis Research & Therapy 2005
Wan-Uk Kim So-Youn Min Mi-La Cho Kyung-Hee Hong Yong-Joo Shin Sung-Hwan Park Chul-Soo Cho

Matrix metalloproteinase-9 (MMP-9) has been implicated in the pathogenesis of cancer, autoimmune disease, and various pathologic conditions characterized by excessive fibrosis. In this study, we investigated the expression of MMP-9 and its clinical significance in systemic sclerosis (SSc). The patients (n = 42) with SSc had higher concentrations of MMP-9 and of tissue inhibitor of metalloprotei...

2017
Jennifer Vandooren Sofie Knoops João L Aldinucci Buzzo Lise Boon Erik Martens Ghislain Opdenakker Elzbieta Kolaczkowska

Gelatinase B or matrix metalloproteinase-9 (MMP-9) (EC 3.4.24.35) is increased in inflammatory processes and cancer, and is associated with disease progression. In part, this is due to MMP-9-mediated degradation of extracellular matrix, facilitating influx of leukocytes into inflamed tissues and invasion or metastasis of cancer cells. MMP-9 is produced as proMMP-9 and its propeptide is subseque...

2017
Chun Gu Fang Wang Zhenwen Zhao Hongyue Wang Xiangfeng Cong Xi Chen

Lysophosphatidic acid (LPA), one of the simplest phospholipid signaling molecules, participates in formation and disruption of atherosclerotic plaque. Matrix metalloproteinases (MMPs) contribute to atherosclerotic plaque rupture by involving in extracellular matrix (ECM) degradation and then thinning fibrous cap. Our previous study demonstrated that macrophage-derived MMP-9 was associated with ...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2000
X Wang J Jung M Asahi W Chwang L Russo M A Moskowitz C E Dixon M E Fini E H Lo

Matrix metalloproteinases (MMPs) belong to a class of extracellular proteinases responsible for maintaining and remodeling the extracellular matrix. In addition to multiple functions in normal physiology, abnormal MMP expression and activity may also participate in the pathophysiology of cerebral disease. Here, we show that MMP-9 (gelatinase B; EC.3.4.24.35) contributes to the pathophysiology o...

Journal: :BMC Musculoskeletal Disorders 2007
Kazuhiro Fukushima Akinori Nakamura Hideho Ueda Katsutoshi Yuasa Kunihiro Yoshida Shin'ichi Takeda Shu-ichi Ikeda

BACKGROUND Matrix metalloproteinases (MMPs) are key regulatory molecules in the formation, remodeling and degradation of all extracellular matrix (ECM) components in both physiological and pathological processes in various tissues. The aim of this study was to examine the involvement of gelatinase MMP family members, MMP-2 and MMP-9, in dystrophin-deficient skeletal muscle. Towards this aim, we...

Journal: :Infection and immunity 2009
Andrew J Heilpern Warren Wertheim Jia He George Perides Roderick T Bronson Linden T Hu

Borrelia burgdorferi, the causative agent of Lyme arthritis, does not produce any exported proteases capable of degrading extracellular matrix despite the fact that it is able to disseminate from a skin insertion site to infect multiple organs. Prior studies have shown that B. burgdorferi induces the host protease, matrix metalloproteinase 9 (MMP-9), and suggested that the induction of MMP-9 ma...

Journal: :Journal of neurochemistry 2007
Andrea M Papp Rita Nyilas Zsuzsanna Szepesi Magor L Lorincz Eszter Takács István Abrahám Nóra Szilágyi Júlia Tóth Péter Medveczky László Szilágyi Gábor Juhász

Up-regulation of matrix metalloproteinase-9 (MMP-9, gelatinase B) in the nervous system has been demonstrated when excitotoxicity-induced tissue remodeling and neuronal death occurs. Induction of MMP-9 by a natural stimulus has not been observed yet. Using RT-PCR and gelatin-zymography we demonstrated MMP-9 induction at transcriptional and protein levels in different structures of the rat eye f...

Journal: :Circulation 2001
M Lindsey K Wedin M D Brown C Keller A J Evans J Smolen A R Burns R D Rossen L Michael M Entman

BACKGROUND A key component of reperfusion of myocardial infarction is an immediate inflammatory response, which enhances tissue repair. Matrix turnover is crucial to tissue repair, and matrix metalloproteinases (MMPs) are key enzymes involved in matrix degradation. The hypothesis tested is that one inflammation-based effector of tissue repair is the secretion and activation of MMP-9 by infiltra...

2014
Guadalupe Martin Víctor Asensi A. Hugo Montes Julio Collazos Victoria Alvarez José A. Carton Francisco Taboada Eulalia Valle-Garay

Matrix-metalloproteases (MMPs) and their tissue-inhibitors (TIMPs), modulated by different single nucleotide polymorphisms (SNPs), are critical in sepsis development. Ninety ICU severely septic and 91 ICU uninfected patients were prospectively studied. MMP-1 (-1607 1G/2G), MMP-3 (-1612 5A/6A), MMP-8 (-799 C/T), MMP-9 (-1562 C/T), and MMP-13 (-77A/G) SNPs were genotyped. Plasma MMPs (-1, -2, -3,...

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