Received November 9, 2016; revised manuscript received February 21, 2017; accepted March 4, 2017; released online March 31, 2017 Time for primary review: 7 days Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University, Yufu (Y.I., K.Y., T.S., H.K., A.F., N.O., H.A., Y.T., M.N., N.T.); Department of Cardiology, Shinbeppu Hospital, Beppu (T.N., E.O., K.W., K.K.), Ja...

Agonists of kainate receptors (KARs) cause both the opening of the associated ion channels and the activation of signalling pathways driven by G-proteins and PKC. Here we report the existence of an unknown mechanism of KAR autoregulation, involving the interplay of this two signalling mechanisms. Repetitive activation of native KARs evoked the rundown of the ionotropic responses in a manner tha...

Vol. 28, No. 5, 2016 637 Received May 27, 2014, Revised December 17, 2014, Accepted for publication August 18, 2015 Corresponding author: Yutaka Hatano, Department of Dermatology, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-Machi, Yufu City, Oita 879-5593, Japan. Tel: 81-97-586-5882, Fax: 81-97-586-5889, E-mail: [email protected] This is an Open Access article distributed unde...

The deductive paradigm has produced notable successes in epidemiology and public health. But while deductive logic has made a substantial contribution to the public health field, it must be recognized that there are also limits to that contribution. This report examines one such limit: the need for non-deductive models in public health reasoning. The findings of a study of public health reasoni...

BECKMAN, ALEXANDER, AND EVELYN SATINOFF. Arousal from hibernation by intrahypothalamic injections of biogenic amines in ground squirrels. Am. J. Physiol. 222(4) : 875-879. 1972.--Injections of low doses of norepinephrine or 5-hydroxytryptamine into the preoptic and anterior area of the hypothalamus in hibernating ground squirrels (Citellus lateralis) initiated complete arousal from hibernation....

Vinculin plays a dynamic role in the assembly of the actin cytoskeleton. A strong interaction between its head and tail domains that regulates binding to other cytoskeletal components is disrupted by acidic phospholipids. Here, we present the crystal structure of the vinculin tail, residues 879-1066. Five amphipathic helices form an antiparallel bundle that resembles exchangeable apolipoprotein...

BACKGROUND The link between AIT and PCOS has been reported on several studies, but it's true pathogenesis is far from being elucidated. In an attempt to provide evidence of the relationship between PCOS and AIT, relevant literature of AIT markers in women with PCOS was reviewed and analyzed. METHODS PubMed, Embase, Medline, Web of Knowledge and the Cochrane trial register were searched with E...

À NOTRE ÉPOQUE DE LA MÉDECINE FONDÉE SUR LES DONNÉES PROBANTES, même les interventions médicales et les protocoles les plus acceptés sont réévalués sur le plan scientifique. Dans ce numéro (page 879), le Dr Olu O. Agboola et ses collègues examinent l’effet qu’a sur le taux de survie le suivi de routine des patientes traitées pour un cancer de l’endomètre. Ils concluent que le protocole standard...

879 www.e-arm.org We appreciate your interest in our study. In this study, we did not focus on lumbar extensor strength. Our interventions were consisted of trunk extensor, flexor, and rotator muscles strength. Isolated lumbar extensor strengthening machine MedX (MedX Holdings Inc., Ocala, FL, USA) was used to compare superficial muscles of trunk and deep spinal muscles strength between baselin...

Bimetallic nanostructured core-shell structures are commonly used as catalysts in a wide variety of reactions. We surmised that the addition of an additional metal would potentially allow catalytic tailoring with the possibility of an increase in activity. Here a tri-metallic catalytic structure, consisting of clustered catalytic Pt on the surface of a Pd shell supported on a rod shaped Au core...