نتایج جستجو برای: 8020

تعداد نتایج: 163  

2018
Laurenson Percy

Esters of crotonic acid were brominated on a multigramme scale using a free radical procedure. A phase transfer catalysed fluorination transformed these species to the 4-fluorobut-2E-enoates reproducibly and at scale (48–53%, ca. 300 mmol). Asymmetric dihydroxylation reactions were then used to transform the butenoate, ultimately into all four diastereoisomers of a versatile fluorinated C4 buil...

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2009
David M. Vail Douglas H. Thamm Hans Reiser Adrian S. Ray Grushenka H.I. Wolfgang William J. Watkins Darius Babusis Ilana N. Henne Michael J. Hawkins Ilene D. Kurzman Robert Jeraj Matt Vanderhoek Susan Plaza Christie Anderson Mackenzie A. Wessel Cecilia Robat Jessica Lawrence Daniel B. Tumas

Purpose: To assess, in dogs with naturally occurring non-Hodgkin's lymphoma, pharmacokinetics, safety, and activity of GS-9219, a prodrug of the nucleotide analogue 9-(2-phosphonylmethoxyethyl) guanine (PMEG), which delivers PMEG and its phosphorylated metabolites to lymphoid cells with preferential cytotoxicity in cells with a high proliferation index such as lymphoid malignancies. Experimenta...

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2015
Anton V. Persikov Joshua L. Wetzel Elizabeth F. Rowland Benjamin L. Oakes Denise J. Xu Mona Singh Marcus B. Noyes

Cys2His2 zinc fingers (C2H2-ZFs) comprise the largest class of metazoan DNA-binding domains. Despite this domain’s well-defined DNA-recognition interface, and its successful use in the design of chimeric proteins capable of targeting genomic regions of interest, much remains unknown about its DNA-binding landscape. To help bridge this gap in fundamental knowledge and to provide a resource for d...

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