It is difficult to construct a control group for trials of adjuvant therapy (Rx) of prostate cancer after radical prostatectomy (RP) due to ethical issues and patient acceptance. We utilized 8 curve-fitting models to estimate the time to 60%, 65%, … 95% chance of progression free survival (PFS) based on the data derived from Kattan post-RP nomogram. The 8 models were systematically applied to a...

Case summary A 6-year-old female neutered domestic shorthair cat from Cyprus was presented with multiple ulcerated skin nodules. Cytology and histopathology of the lesions revealed granulomatous dermatitis with intracytoplasmic organisms, consistent with amastigotes of Leishmania species. Biochemistry identified a mild hyperproteinaemia. Blood extraction and PCR detected Leishmania species, Hep...

OBJECTIVES We determined the effect of clopidogrel dosing on the incidence of nonresponsiveness (NR) and high post-treatment platelet aggregation (post-PA). BACKGROUND We have reported NR after a 300-mg loading dose. Limited information is available on the comparative effect of a 600-mg loading dose on the incidence of NR and high post-PA. METHODS Clopidogrel responsiveness and post-PA were...

background: very few studies have been performed on small populations about the links between employment and bariatric surgery. objective: to determine if rates of employment are increased among patients who have undergone bariatric surgery, to assess their post-operative health consequences (post-prandial weakness, diarrhea), and patients' ability to maintain post-operative advice (ie, 30 minu...

BACKGROUND Previously we showed that reduced availability of the essential amino acid tryptophan per se attenuates post-transcriptional control of interleukin (IL)-6 and IL-8 leading to hyperresponsive production of these inflammatory mediators by airway epithelial cells. Availability of the non-essential amino acid arginine in the inflamed airway mucosa of patients with asthma is reduced marke...

the purpose of this study was to determine the effect of a session of endurance and sprint exercises on plasma anp in male athlete students. for this reason, 24 male athlete students were volunteered and randomized into endurance (n=8, age 24.5± 2.1 years, height 176.3± 3.5 cm, weight 71.75±4.6 kg), sprint (n=8, age 22.1±2.2 years, height 176.1±4.8 cm, weight 67.6±7.4 kg) and control groups (n=...

N-glycosylation of proteins in endoplasmic reticulum is critical for protein quality control. We showed here a post-translational N-glycosylation affected by the HRD1 E3 ubiquitin ligase. Both WT- and E3-defective C329S-HRD1 decreased the level of high mannose form of ABCG8, a protein that heterodimerizes with ABCG5 to control sterol balance. Meanwhile, HRD1 increased the non-glycosylated ABCG8...

WPSAR Vol 6, Suppl 1, 2015 | doi: 10.5365/wpsar.2015.6.3.HYN_020 www.wpro.who.int/wpsar 21 a Offi ce of the WHO Representative in the Philippines, Sta Cruz, Manila, Philippines. b Regional Offi ce 8, Department of Health, Tacloban City, Philippines. Submitted: 6 August 2015; Published: 6 November 2015 doi: 10.5365/wpsar.2015.6.3.HYN_020 Surveillance for and issues relating to noncommunicable di...

The objective of this study was to identify relevant descriptors of ruminal pH post-prandial evolution that can replace the mean pH (considered unsatisfactory). These descriptors are to be used in the attempts to predict ruminal pH from dietary characteristics, in order to quantify the potential of a diet to induce subacute ruminal acidosis from its intrinsic characteristics. A total of 219 pH ...

BACKGROUND Post-breakfast/post-challenge plasma glucose (PG) concentrations were studied less in young normal weight Japanese women. We addressed these issues. METHODS Two separate groups of female collegiate athletes and female untrained students underwent either a standardized meal test or a standard 75-g oral glucose tolerance test, but not both. Frequency of women whose post-breakfast/pos...